Recombinant Human IL-13 (carri

Recombinant Human IL-13 (carrier-free)
Catalog# / Size 571102 / 10 µg
571104 / 25 µg
571106 / 100 µg
Regulatory Status RUO
Other Names ALRH, BHR1, P600, IL-13, MGC116786, MGC116788, MGC116789, IL13
Description Human IL-13 was initially cloned from cDNA libraries of activated T cells. IL-13 is an
immunoregulatory cytokine secreted predominantly by activated T(H)2 cells, and it is a key
mediator in the pathogenesis of allergic inflammation. IL-13 shares many functional
properties with IL-4, and they share a common receptor subunit, the alpha subunit of the
IL-4 receptor (IL-4Ralpha). IL-13 mediates its effects by interacting with a complex receptor
system comprised of IL-4Ralpha and two IL-13 binding proteins, IL-13Ralpha1 and IL13Ralpha2. Ligation of the IL-13 receptor complex results in signaling via the insulin
receptor substrate (IRS)-1 and 2 and STAT-6 pathways. IL-13, like IL-4, is a cytokine
produced by T(H)2 type helper T cells in response to signaling through the T cell antigen
receptor and by mast cells and basophils upon cross-linkage of the high-affinity receptor
for immunoglobulin E (IgE). IL-13 has been implicated in airway hypersensitivity and
mucus hypersecretion, inflammatory bowel disease, and parasitic nematode expulsion.
Product Details
Source Human IL-13, amino acids Gly21-Asn132 (Accession# X69079), was expressed in E. coli.
Molecular Mass The 112 amino acid recombinant protein has a predicted molecular mass of 12,344 Da. The
DTT-reduced and non-reduced protein migrate at approximately 9kDa by SDS-PAGE. The Nterminal amino acid is Glycine.
Purity Purity is >98%, as determined by Coomassie stained SDS-PAGE.
Formulation 0.22µm filtered protein solution is in 10mM NaH2PO4, 150mM NaCl, pH 7.2.
Endotoxin Level Endotoxin level is < 0.1 EU/µg (< 0.01ng/µg) protein as determined by the LAL method.