InvivoCrown In vivo blocking o

InVivoPro Anti-Mouse PD-1(CD279) in vivo antibody, Clone RMP1-14InVivoPro Anti-Mouse PD-1(CD279) in vivo antibody, Clone RMP1-14Rat IgG2a κRat IgG2a κRMP1-14RMP1-14PD-1PD-1Programmed Death-1, CD279, PD-1Programmed Death-1, CD279, PD-1IV0105 or Rat IgG2a Isotype Control IV0105 or Rat IgG2a Isotype Control PBS, pH 7.2, contains no stabilizers or preservativesPBS, pH 7.2, contains no stabilizers or preservativesMouseMouseRatRat200-500 μg per mouse; or 10 mg/kg. This range is based off the most recent publication data using the RMP1-14 clone in vivo. Each investigator should determine their own optimal working dilution for specific applications.200-500 μg per mouse; or 10 mg/kg. This range is based off the most recent publication data using the RMP1-14 clone in vivo. Each investigator should determine their own optimal working dilution for specific applications.766766Koikawa, Kazuhiro, et al. "Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy." Cell 184.18 (2021): 4753-4771. Fan, Hao, et al. "Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity." Nature 623.7989 (2023): 1034-1043. Wang, Xiafeng, et al. "STING agonist-based ER-targeting molecules boost antigen cross-presentation." Nature (2025): 1-9.Koikawa, Kazuhiro, et al. "Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy." Cell 184.18 (2021): 4753-4771. Fan, Hao, et al. "Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity." Nature 623.7989 (2023): 1034-1043. Wang, Xiafeng, et al. "STING agonist-based ER-targeting molecules boost antigen cross-presentation." Nature (2025): 1-9.CD279, also known as programmed death-1 (PD-1) is a 50-55 kD immunoglobulin superfamily member. PD-1 is expressed on a subset of CD4-CD8- thymocytes, and on activated T and B cells. The PD-1 ligands, PD-L1 (also known as B7-H1) and PD-L2 (B7-DC), are members of the B7 immunoglobulin superfamily. This RMP1-14 antibody has been reported to block the binding of PD-1 to its ligands (B7-H1 and B7-DC) and to inhibit T cell proliferation and cytokine production.CD279, also known as programmed death-1 (PD-1) is a 50-55 kD immunoglobulin superfamily member. PD-1 is expressed on a subset of CD4-CD8- thymocytes, and on activated T and B cells. The PD-1 ligands, PD-L1 (also known as B7-H1) and PD-L2 (B7-DC), are members of the B7 immunoglobulin superfamily. This RMP1-14 antibody has been reported to block the binding of PD-1 to its ligands (B7-H1 and B7-DC) and to inhibit T cell proliferation and cytokine production.In vivo blocking of PD-1/PD-L1 signalingIn vivo blocking of PD-1/PD-L1 signalingprotein A or Gprotein A or GThis antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles.This antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles.2-8°C with blue ice2-8°C with blue iceLot specific, generally ≥ 5.0 mg/mlLot specific, generally ≥ 5.0 mg/ml12 months from the date of receipt if stored as recommended12 months from the date of receipt if stored as recommendedPBS Buffer, PH 7.2, with no carrier protein, or preservatives.PBS Buffer, PH 7.2, with no carrier protein, or preservatives.0.2 μM filtered0.2 μM filtered≤ 1.0 EU/mg, by the LAL method≤ 1.0 EU/mg, by the LAL method0.990.99可替换BioXCell产品货号为BE0146