- ￥5130
- BioLegend
- 142404
- 2025年07月15日
- 免疫荧光，流式
- 大鼠
- 小鼠
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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
PE anti-mouse CD169 (Siglec-1)
- 抗体英文名：
PE anti-mouse CD169 (Siglec-1)
- 应用范围：
免疫荧光，流式
- 宿主：
大鼠
- 供应商：
上海善然生物
- 库存：
现货
- 抗原来源：
大鼠
- 保质期：
2-3年左右
- 适应物种：
小鼠
- 标记物：
PE
- 克隆性：
单克隆
- 保存条件：
2-8度
- 形态：
液体
- 规格：
100 μg
PE anti-mouse CD169 (Siglec-1) Antibody
3D6.112
Catalog# / Size 142403 / 25 µg
142404 / 100 µg
Clone
Regulatory Status RUO
Other Names Sialic acid binding Ig-like lectin 1 (Siglec-1), Sialoadhesin (Sn)
Isotype Rat IgG2a, κ
Description CD169, also known as Siglec-1 and Sialoadhesin (Sn), is a type I lectin containing 17 immunoglobulin (Ig)
domains (one variable domain and 16 constant domains). CD169 binds to sialic acids, which can be found on
PSGL-1, CD43, CD206, and CD227. By its affinity to α2, 3-linked sialic acid, it is involved in macrophage binding
to different cell types such as granulocytes, monocytes, NK, B, and T cells. CD169 was initially identified as a
sialic acid-dependent sheep erythrocyte receptor (SER) on resident bone marrow cells of mice. It has been
identified as highly expressed on resident bone marrow macrophages which plays an important role in retention
of stem cells in mesenchymal stem cell niche. It is also found on some specific subsets of tissue macrophages in
spleen, lymph nodes, bone marrow, liver, colon, lungs, and cancer cells. Evidence suggest that CD169-positive
macrophages serve as lymph node-resident APCs to dominate early activation of tumor antigen-specific CD8 T
cells and invariant NK cell.
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Product Details
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Rat
Immunogen Purified Native Sialoadhesin from spleen
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to
light. Do not freeze.
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