- ￥3605
- BioLegend
- 134716
- 美国
- 2025年07月16日
- 免疫荧光，流式
- 大鼠
- 小鼠
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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
Biotin anti-mouse CD146
- 抗体英文名：
Biotin anti-mouse CD146
- 浓度：
0.5 mg/mL
- 应用范围：
免疫荧光，流式
- 宿主：
大鼠
- 供应商：
上海善然生物
- 库存：
现货
- 抗原来源：
大鼠
- 保质期：
2-3年左右
- 适应物种：
小鼠
- 标记物：
Biotin
- 克隆性：
单克隆
- 保存条件：
2-8度
- 形态：
液体
- 规格：
100 μg
Biotin anti-mouse CD146 Antibody
ME-9F1
Catalog# / Size 134716 / 100 µg
Clone
Regulatory Status RUO
Other Names S-Endo 1 antigen, MUC18, MCAM, Mel-CAM, A32 antigen
Isotype Rat IgG2a, κ
Description CD146, also known as melanoma cell adhesion molecule (MCAM or Mel-CAM), MUC18, SEndo1, and A32 antigen, is an integral membrane glycoprotein that belongs to the Ig
superfamily. CD146 is strongly expressed by murine vascular endothelial cells. It is expressed
on about 30% of neutrophils and 60% of NK cells. Unlike in humans, CD146 is undetectable
on monocytes, dendritic cells, T cells, NKT cells, B cells, or smooth muscle cells in mouse. It
has been reported that an increase in CD146 expression is associated with NK cell
maturation. Combined with using CD27 and CD11b staining, CD146 may be an alternative
marker to detect final stages of NK cell maturation and define NK cell subsets. CD146 NK
cells were found to be less cytotoxic and to produce less IFNγ than CD146- NK cells upon
stimulation with target cells or activating antibodies. The role of CD146 on NK cell migration
has yet to be investigated. The identification of CD146 ligand(s) will be crucial to address this
issue.
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Product Details
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Rat
Immunogen Endothelial cell line TME-3H3
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation The antibody was purified by affinity chromatography and conjugated with biotin under optimal
conditions.
Concentration 0.5 mg/ml
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
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