Rat TP53 (Tumor Protein 53) EL

TP53 Mutation Detection by SSCP and Sequencing

The TP53 tumor suppressor gene on chromosome 17p13.1 contains 11 exons and encodes a nuclear phosphoprotein of 53 kDa, a transcription factor involved in the regulation of the cell cycle (1 ). Normal p53 protein functions as a cell cycle

Science：直击肿瘤命门，Shibin Zhou 等开发靶向 TP53 突变的双特异性抗体

p53 基因是人体内最重要的抑癌基因之一，扮演着人体基因组守护者的角色。 p53 缺失会使得表达致癌基因的细胞无限增殖，从而直接导致癌症发生；p53 缺失还会导致存活的子代细胞中基因突变负荷增加，间接地促进癌症的发生。编码 p53 的 TP53 基因也是人类癌症中最常出现突变的抑癌基因。因此，一般认为，TP53 基因的突变常常与癌症的发生和患者的不良预后相关 [1]。 关于 TP53 基因的研究一直是肿瘤治疗领域的热点，科学家们也一直在苦苦探寻靶向 TP53 的肿瘤治疗药物，但是至今还没有针

TP53, hChk2, and the Li-Fraumeni Syndrome

. One of the most widely used was defined by Birch et al. (4 ) as Li-Fraumeni-like (LFL) and is a proband with any childhood tumor, or sarcoma, brain tumor, or adrenocortical tumor under 45 years, plus a first- or second-degree relative with a typical LFS tumor at any age