豚鼠 SIGLEC3 (Sialic Acid Bindin

Binding and Inhibition Assays for Siglecs

to those commonly employed in protein-protein interactions, several important aspects have to be taken into account in binding assays with lectin-like receptors such as Siglecs, sialic acid-recognizing immunoglobulin-like lectins. This chapter describes experimental

解码Siglec家族：关键成员、作用机制与实验研究策略

receptor enables effective adoptive T-cell therapy for B-cell malignancies. Blood. 2026;147 (10):1058-1069. [14] Razi N,Varki A. Masking and unmasking of the sialic acid-binding lectin activity of CD22 (Siglec-2) on B lymphocytes. Proc Natl Acad Sci U S

古洛糖酸 gulonic acid

醛酸的一种，L型相当于 L-古洛糖一位上的醛基被羧基置换的形态，或 D-葡糖醛酸的一位醛基变成醇基。在大多数动植物中，以古洛糖酸γ -内酯形态存在。古洛糖酸可由特异的氧化酶脱氢反应而变成维生素 C（ L-抗坏血酸）。因为人、猿、豚鼠中不具有这种酶，所以必须从外界摄取维生素 C。另一方面，则存在着 L-古洛糖酸→ 3-酮 -L-古洛糖酸→ L-木酮糖→ L-木糖醇→ D-木酮糖的代谢途径，代表性的戊糖尿症，可在尿中发现古洛糖酸的代谢中间物质 L-木酮糖。