- ￥668 - 3499
- DIMA BIOTECH/缔码生物
- 武汉
- PME101467
- 2025年11月27日
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- 详细信息
- 技术资料
- 保存条件：
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 保质期：
12个月
- 英文名：
Recombinant human ITGAV protein with C-terminal 6×His tag and human ITGB5 protein with C-terminal human Fc tag
- 库存：
In Stock
- 供应商：
缔码生物（武汉）科技有限公司
- 规格：
10μg/50μg/100μg
| 规格： | 10μg | 产品价格： | ￥668.0 |
|---|---|---|---|
| 规格： | 50μg | 产品价格： | ￥2300.0 |
| 规格： | 100μg | 产品价格： | ￥3499.0 |
| 产品类型 | ECD Proteins |
|---|---|
| 靶点 | ITGAV and ITGB5 |
| Uniprot ID | P06756 and P18084 |
| 别名 | CD51; MSK8; VNRA; VTNR and ITB5; Integrin beta-5 |
| 背景 | Integrin alpha V beta 5 (ITGAV & ITGB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAV & ITGB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAV & ITGB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency. |
| 产品英文名称 | Recombinant human ITGAV protein with C-terminal 6×His tag and human ITGB5 protein with C-terminal human Fc tag |
| 分子结构 | ITGAV(Phe31-Val992) 6×His tag and ITGB5(Gly24-Asn719) hFc(Glu99-Ala330) |
| 分子量 | The protein has a predicted molecular mass of 107.1 and 102.7 kDa after removal of the signal peptide. |
| 纯度 | The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining. |
| 标签 | C-6×His tag and C-Human Fc tag |
| 有无偶联 | Unconjugated |
| 表达宿主 | HEK293 |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| 货期 | In Stock |
| 储存与运输 | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| 应用范围 | Research use only |
Figure 1. Human ITGAV and ITGB5 Protein, His Tag and hFc Tag on SDS-PAGE under reducing condition.
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人ITGAV and ITGB5重组蛋白/Human ITGAV and ITGB5 Heterodimer Protein, His Tag and hFc Tag
￥668 - 3499
