- 询价
- Promab
- 美国
- PMB-B00063
- 2025年07月12日
- Human DLL3
- 66
- Human
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- 文献和实验
- 技术资料
- 免疫原：
CHO cells
- 亚型：
Human DLL3
- 形态：
Flow cytometry, animal model study
- 保存条件：
Store at 4°C 1 month, store at -20°C to -70°C 12 month. protected from prolonged exposure to light. Avoid freeze/thaw cycles.
- 克隆性：
Human DLL3
- 标记物：
Flow cytometry, animal model study
- 适应物种：
Human
- 保质期：
CHO cells
- 抗原来源：
Human DLL3
- 目录编号：
Flow cytometry, animal model study
- 级别：
77
- 库存：
10
- 供应商：
艾美捷科技
- 宿主：
66
- 应用范围：
Human DLL3
- 浓度：
55
- 靶点：
CHO cells
- 抗体英文名：
Rovalpituzumab Biosimilar, Human DLL3 Monoclonal Antibody
- 抗体名：
Rovalpituzumab 生物类似药, 人 DLL3 单克隆抗体
Rovalpituzumab 生物类似药, 人 DLL3 单克隆抗体，Rovalpituzumab Biosimilar, Human DLL3 Monoclonal Antibody，Rovalpituzumab Biosimilar, Human DLL3 Monoclonal Antibody,Rovalpituzumab 生物类似药, 人 DLL3 单克隆抗体
产品名称：-In vivo级抗体试剂
产品货号：PMB-B00063
产品规格：询价/1mg/5mg/20mg
应用类型：Flow cytometry, animal model study
What is rovalpituzumab biosimilar research grade? Rovalpituzumab is a humanized IgG1-kappa monoclonal antibody against the human Delta-like 3 protein (DLL3), which is an atypical Notch ligand that has been implicated in regulation of cell development and cell fate decisions, and is a downstream target of achaetescute homolog-1 (ASCL1), suggesting its role in neuroendocrine tumorigenesis. DLL3 is expressed in more than 80% of patients with small-cell lung cancer (SCLC) and other neuroendocrine tumors, but has little to no expression in normal tissues or non-neuroendocrine tumor types. DLL3 expression appears to be stable over time in SCLC tumors pre- and post-chemotherapy. Although DLL3 is mostly found within the Golgi apparatus under physiological conditions, it may reach the cell surface in case of overexpression and lead to Notch inhibition in cis. Rovalpituzumab tesirine (Rova-T) is a first-in-class antibody–drug conjugate (ADC) against DLL3, and composed of SC16, a humanized IgG1 antibody against DLL3, conjugated to the cytotoxic pyrrolobenzodiazepine (PBD) dimer D6.5 (SC-DR002) via a protease-cleavable linker. Rova-T selectively binds to DLL3 on target-expressing cells, is internalized, and upon proteolytic cleavage releases the toxin. PBD dimers then bind to the DNA minor groove where they form covalent adducts causing stalling of the replication forks, cell-cycle arrest at the G2–M boundary, and apoptosis. Rovalpituzumab biosimilar uses the same protein sequences as the therapeutic antibody rovalpituzumab.
-In vivo级抗体试剂Store at 4°C 1 month, store at -20°C to -70°C 12 month. protected from prolonged exposure to light. Avoid freeze/thaw cycles.
点击：-In vivo级抗体试剂更多Promab产品信息价格，货期，产品说明，百度搜“艾美捷科技”进入官网网站，查看具体产品且快速下单。
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文献和实验
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