Cholesterol‑Undecanoate‑Glucos

一种基于葡萄糖的脂质缀合物；已用于生成脑靶向脂质体；与磷脂形成稳定有序的双层，葡萄糖部分朝外，可被血脑屏障上的GLUT1识别；与荧光标记的非胆固醇十一酸葡萄糖缀合物脂质体（包覆青蒿琥酯和川芎嗪）相比，静脉内和鼻内施用含有胆固醇十一酸葡萄糖缀合物并包覆青蒿琥酯和川芎嗪的荧光标记脂质体可增加恶性疟原虫诱发的脑疟疾病例小鼠的脑荧光强度并降低感染率。A glucose-based lipid conjugate; has been used in the generation of brain-targeted liposomes; forms a stable, ordered bilayer with phospholipids with the glucose moiety facing outward to be recognized by GLUT1 on the blood-brain barrier; intravenous and intranasal administration of fluorescently labeled liposomes containing cholesterol-undecanoate-glucose conjugate and encapsulating artesunate and ligustrazine induces increased brain fluorescence intensity and reduced infection rate in a mouse model of P. falciparum-induced cerebral malaria when compared with fluorescently labeled non-cholesterol-undecanoate-glucose conjugate-containing liposomes encapsulating artesunate and ligustrazine.分子式C50H80O9分子量825.2C[C@]12CC[C@H](OC(CCCCCCCCCCOC3=CC=C(O[C@H](O[C@@H]4CO)[C@H](O)[C@@H](O)[C@@H]4O)C=C3)=O)CC1=CC[C@]5([H])[C@]2([H])CC[C@@]6(C)[C@@]5([H])CC[C@]6([H])[C@@H](CCCC(C)C)C