IMR-1A

Notch三元复合物形成的抑制剂(IC50=0.5µM)和IMR-1的活性代谢物；与Notch的细胞内结构域结合(Kd=2.9µM)并破坏Notch与MAM-1和CSL转录因子之间的蛋白质-蛋白质相互作用；在25µM时增加原发性脉络丛癌细胞的多纤毛。An inhibitor of Notch ternary complex formation (IC50 = 0.5 µM) and an active metabolite of IMR-1; binds to the intracellular domain of Notch (Kd = 2.9 µM) and disrupts the protein-protein interactions between Notch and MAM-1 and CSL transcription factor; increases multiciliation in primary choroid plexus cancer cells at 25 µM.分子式C13H11NO5S2分子量325.4O=C(COC1=CC=C(C=C2SC(NC2=O)=S)C=C1OC)O