FSEN1

一种FSP1抑制剂（IC50=313nM），对FSP1的选择性优于NQO1（NQO1的IC50>100µM）。该抑制剂在GPX4基因敲除的H460细胞中诱导细胞死亡（EC50=69.36nM）。在10-1,000nM的浓度范围内，该抑制剂可增强多种癌细胞对(1S,3R)-RSL3诱导的铁死亡的敏感性。此外，该抑制剂还可增强H460Cas9细胞对青蒿琥酯或FINO2诱导的细胞死亡的敏感性。An inhibitor of FSP1 (IC50 = 313 nM); selective for FSP1 over NQO1 (IC50 = >100 µM); induces cell death in GPX4-/- H460 cells (EC50 = 69.36 nM); sensitizes various cancer cells to (1S,3R)-RSL3-induced ferroptosis from 10-1,000 nM; sensitizes H460Cas9 cells to dihydroartemisinin- or FINO2-induced cell death.分子式C22H22BrN5OS分子量484.4COC(C=C1)=CC=C1N(CC2)CCN2CC3=CN4C(C5=CC=C(Br)C=C5)=NN=C4S3