KY 19382

CF5-Dvl蛋白质-蛋白质相互作用的抑制剂(IC50=19nM)；GSK3β的抑制剂(IC50=10nM)；在100nM时增加ATDC-5软骨细胞中编码WISP-1和Axin2（Wnt通路激活的标志物）的mRNA表达；在100nM时增加ATDC-5细胞中β-catenin的核水平和细胞浆水平；在0.1mg/kg/天时增加青春期小鼠的骨板生长和胫骨长度。An inhibitor of the CF5-Dvl protein-protein interaction (IC50 = 19 nM); an inhibitor of GSK3β (IC50 = 10 nM); increases expression of the mRNA encoding WISP-1 and Axin2, markers of Wnt pathway activation, in ATDC-5 chondrogenic cells at 100 nM; increases nuclear and cytosolic levels of β-catenin in ATDC-5 cells at 100 nM; increases bone plate growth and tibia length in adolescent mice at 0.1 mg/kg per day.分子式C17H11Cl2N3O2分子量360.2O=C1NC2=C(C1=C3NC4=C(C3=NOC)C=CC=C4)C=C(Cl)C(Cl)=C2