EC330

一种LIF抑制剂；与LIFR结合，选择性地对异位过表达LIF的MCF-7细胞(IC50=0.075µM)产生细胞毒性，而非对未过表达LIF的MCF-7细胞(IC50=0.245µM)产生细胞毒性；分别在5nM和15nM时降低异位LIF表达引起的MCF-7和MDA-MB-231细胞迁移增加；在293T和786-O细胞中诱导铁死亡；在小鼠异种移植模型中使用异位LIF表达的MDA-MB-231细胞比使用没有异位LIF表达的MDA-MB-231细胞时更能减轻肿瘤负担。A LIF inhibitor; binds to LIFR and is selectively cytotoxic to MCF-7 cells ectopically overexpressing LIF (IC50 = 0.075 µM) over non-LIF-overexpressing MCF-7 cells (IC50 = 0.245 µM); reduces ectopic LIF expression-induced increases in the migration of MCF-7 and MDA-MB-231 cells at 5 and 15 nM, respectively; induces ferroptosis in 293T and 786-O cells; reduces tumor burden to a greater extent in a mouse xenograft model using MDA-MB-231 cells with ectopic LIF expression than when using MDA-MB-231 cells without ectopic LIF expression.分子式C30H32F2O2分子量462.6C[C@@]12[C@](CC[C@@]2(O)C(F)(F)C#C)([H])[C@@]3([H])C([C@@H](C4=CC=C(C5CC5)C=C4)C1)=C6C(CC3)=CC(CC6)=O