IRBP (1-20) (human, rat) (trif

实验性自身免疫性葡萄膜视网膜炎的肽诱导剂；在3µM浓度下增加小鼠原代脾淋巴细胞分泌的IL-4、IL-5和IL-6水平；免疫和再次攻击会增加IFN-γ缺乏小鼠的耳朵肿胀；在同一只小鼠中诱发眼部血管炎症、免疫细胞浸润和感光层损伤以及视网膜脱离。A peptide inducer of experimental autoimmune uveoretinitis; increases the levels of IL-4, IL-5, and IL-6 secreted from primary mouse spleen lymphocytes at 3 µM; immunization and rechallenge increases ear swelling in IFN-γ-deficient mice; induces ocular blood vessel inflammation, immune cell infiltration, and photoreceptor layer damage, as well as retinal detachment, in the same mice.分子式C101H164N24O28S • XCF3COOH分子量2194.6OC(C(F)(F)F)=O.O=C(N1CCC[C@H]1C(N[C@]([C@H](O)C)([H])C(N[C@@H](CC2=CNC=N2)C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N3CCC[C@H]3C(N[C@@H](CO)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CCSC)C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(O)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)C)=O)=O)=O)CC(C)C)=O)=O)CC(C)C)=O)=O)=O)=O)CC4=CC=CC=C4)=O)CC(C)C)=O)=O)=O)CN[H]