Antrodin A

具有抗病毒和保肝活性的微生物代谢物；HCV蛋白酶抑制剂（IC50=0.9µg/ml）；降低HSV-1或HSV-2感染的Vero细胞的细胞毒性（IC50s分别为5.8和5.5µg/ml）；以浓度依赖性方式减少HSV-1或HSV-2感染的Vero细胞中的病毒斑块形成；以每天200mg/kg的剂量抑制酒精引起的小鼠ALD模型中血清甘油三酯水平升高和血清HDL水平降低；还可防止酒精引起的肝脏脂质积累和血清ALT和AST活性增加，以及同一模型中小鼠离体肝脏中MDA、SOD和过氧化氢酶活性和GSH水平降低。A microbial metabolite with antiviral and hepatoprotective activities; an inhibitor of HCV protease (IC50 = 0.9 µg/ml); reduces cytotoxicity in Vero cells infected with HSV-1 or HSV-2 (IC50s = 5.8 and 5.5 µg/ml, respectively); decreases viral plaque formation in Vero cells infected with HSV-1 or HSV-2 in a concentration-dependent manner; inhibits alcohol-induced increases in serum triglyceride levels and decreases in serum HDL levels in a mouse model of ALD at 200 mg/kg per day; also prevents alcohol-induced increases in hepatic lipid accumulation and the activity of serum ALT and AST, as well as decreases in the activity of MDA, SOD, and catalase and in the levels of GSH in isolated mouse liver in the same model.分子式C19H22O4分子量314.4C/C(C)=C/COC1=CC=C(C=C1)C(C(O2)=O)=C(CC(C)C)C2=O