R18 (trifluoroacetate salt)

14-3-3-Raf-1蛋白质-蛋白质相互作用的肽抑制剂；与14-3-3τ、-β和-ζ结合（Kds分别为7.1、7和8.9nM），并在5nM的过滤结合试验中抑制14-3-3τ与Raf-1结合；抑制14-3-3ζ介导的保护Raf-1免受磷酸酶诱导的失活。A peptide inhibitor of the 14-3-3-Raf-1 protein-protein interaction; binds to 14-3-3τ, -β, and -ζ (Kds = 7.1, 7, and 8.9 nM, respectively) and inhibits 14-3-3τ binding to Raf-1 in a filter binding assay at 5 nM; inhibits 14-3-3ζ-mediated protection of Raf-1 from phosphatase-induced inactivation.分子式C101H157N27O29S3 • XCF3COOH分子量2309.7O=C(N1[C@@H](CCC1)C(O)=O)[C@H](CC(C)C)NC([C@H](CS)NC([C@H](CCSC)NC([C@H](CC(N)=O)NC([C@H](C)NC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H]2N(C([C@@H](NC([C@H](CS)NC([C@H](CC3=CN=CN3)NC(C4CCCN4)=O)=O)=O)C(C)C)=O)CCC2)=O)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O