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- 辰辉创聚生物
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- NBL-242628
- 2025年07月10日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Short term 4℃; Long term -20℃.
- 保质期：
见COA
- 英文名：
Recombinant Human Fc gamma RI/CD64, Avi-His-tag
- 库存：
大量
- 供应商：
北京辰辉创聚生物技术有限公司
- 规格：
100ug;1mg;Bulk
| 产品信息
品名:NebuSelect™ Recombinant Human Fc gamma RI/CD64, Avi-His-tag
货号:NBL-242628
品牌:Nebulabio
规格:100ug；1mg；Bulk
| 产品描述
NebuSelect™ Recombinant Human Fc gamma RI/CD64, Avi-His-tag(Cat#NBL-242628) is expressed in HEK293 with His tag and Avi tag at the C-Terminus.It contains Gln16-Pro288.
| 产品属性
表达系统:HEK293
标签:Avi-His-tag
靶点名称:Fc gamma RI/CD64
物种：Human
分子量：The protein has a predicted MW of 33.5 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Bis-Tris PAGE result.
氨基酸序列：
Accession: P12314-1
纯度:＞95%
内毒素：＜1EU/ug(LAL Method)
储存运输条件: Short term 4℃; Long term -20℃.
| 靶点信息
The Fc gamma Rs have been divided into three classes based on close relationships in their extracellular domains; these groups are designated Fc gamma- RI (also known as CD64), Fc gamma- RII (CD32), and Fc gamma- RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type.
For Research Use Only!
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文献和实验Assessing Fc Glycan Heterogeneity of Therapeutic Recombinant Monoclonal Antibodies Using NP-HPLC
or plants. Glycans present in the Fc region can affect functions of rMAbs. These Fc glycans are heterogeneous and impact binding of rMAbs to Fc gamma receptors (FcγRs) and C1q protein. As a result Fc glycans affect antibody-dependent cellular cytotoxicity
Capture and Qualitative Analysis of the Activated Fc Receptor Complex from Live Cells
Marshall, J.G., Booth, J.W., Stambolic, V., Mak, T., Balla, T., Schreiber, A.D., Meyer, T., and Grinstein, S. 2001. Restricted accumulation of phosphatidylinositol 3‐kinase products in a plasmalemmal subdomain during Fc gamma receptor‐mediated
;RI(CD64)和FcγRⅡ(CD32)，IgG尤其是人IgG1和IgG3亚类对于调理吞噬起主要作用。嗜酸性粒细胞具有亲和力FcγRⅡ，IgE与相应抗原结合后可促进嗜酸性粒细胞的吞噬作用。抗体的调理机制一般认为是：①抗体在抗原颗粒和吞噬细胞之间“搭桥”，从而加强了吞噬细胞的吞噬作用;②抗体与相应颗粒性抗原结合后，改变抗原表面电荷，降低吞噬细胞与抗原之间的静电斥力;③抗体可中和某些细菌表面的抗吞噬物质如肺炎双球菌的荚膜，使吞噬细胞易于吞噬;④吞噬细胞FcR结合抗原抗体复合
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