- 询价
- 辰辉创聚生物
- 中国
- NBL-242700
- 2025年07月13日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Short term 4℃; Long term -20℃.
- 保质期：
见COA
- 英文名：
Recombinant Mouse EREG, hFc-tag
- 库存：
大量
- 供应商：
北京辰辉创聚生物技术有限公司
- 规格：
100ug;1mg;Bulk
| 产品信息
品名:NebuSelect™ Recombinant Mouse EREG, hFc-tag
货号:NBL-242700
品牌:Nebulabio
规格:100ug；1mg；Bulk
| 产品描述
NebuSelect™ Recombinant Mouse EREG, hFc-tag(Cat#NBL-242700) is expressed in HEK293 with hFc tag at the N-Terminus.It contains Val56-Leu101.
| 产品属性
表达系统:HEK293
标签:hFc-tag
靶点名称:EREG
物种：Mouse
分子量：The protein has a predicted MW of 32.7 kDa. Due to glycosylation, the protein migrates to 37-40 kDa based on Bis-Tris PAGE result.
氨基酸序列：Val56-Leu101
Accession: Q61521
纯度:＞95%
内毒素：＜1EU/ug(LAL Method)
储存运输条件: Short term 4℃; Long term -20℃.
| 靶点信息
Epidermal growth factor receptor (EGFR) regulates many crucial cellular programs, with seven different activating ligands shaping cell signaling in distinct ways.EGFR ligands epiregulin (EREG) and epigen (EPGN) stabilize different dimeric conformations of the EGFR extracellular region. As a consequence, EREG or EPGN induce less stable EGFR dimers than EGF-making them partial agonists of EGFR dimerization. Unexpectedly, this weakened dimerization elicits more sustained EGFR signaling than seen with EGF, provoking responses in breast cancer cells associated with differentiation rather than proliferation.
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文献和实验in the expressed sequence tag or unannotated DNA databases and were novel proteins of unknown function. Since that time, we have been using various molecular biological approaches to determine the functions of some of these proteins
to directly answer key biological questions. We believe that a similar strategy could be adopted with transgenic or knockout mouse work, particularly in cases where there is no obvious phenotype. [NextPage] Proteome mining
1. 前言 用蛋白质组学鉴别植物蛋白质经常遇到植物基因组序列数据量不够的问题。只有拟南芥和水稻被全部测序，这就意味着只有极少情况下可以专门使用质谱分析法（MS) 鉴别蛋白质，通常是用拟南芥这种模式植物 [ 1，2] 。在其他情况下，MS 测序可以同时用 Edman 测序 [ 3,4] 来测定氨基酸末端序列。另一种方法是在用光谱分析法测得末端序列后鉴别蛋白质，然后和已知序列的基因比对 [ 1，3，5，6] 。总的来说，用已知基因组序列的模式植物研究极大推进了植物蛋白
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