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Anti-p16-INK4A, clone D25-L, R

ecombinant Mouse Monoclonal Ab
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  • ¥860
  • Elucigen Biosciences
  • EMS0087
  • 2025年08月13日
  • ICC, WB, Flow
  • Mouse
  • Human
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  • 企业认证

    • 详细信息
    • 文献和实验
    • 技术资料
    • 亚型

      Mouse / IgG1

    • 形态

      Liquid

    • 保存条件

      -20°C

    • 克隆性

      Monoclonal

    • 标记物

      Unconjugated

    • 适应物种

      Human

    • 保质期

      12 months from the shipping date of the product.

    • 抗原来源

      Human

    • 目录编号

      EMS0087

    • 级别

      Primary Antibodies

    • 库存

      Available

    • 供应商

      Elucigen Biosciences

    • 宿主

      Mouse

    • 应用范围

      ICC, WB, Flow

    • 浓度

      0.5 mg/mL

    • 靶点

      P42771

    • 抗体名

      Anti-p16-INK4A, clone D25-L, Recombinant Mouse Monoclonal Ab

    • 规格

      25μg/100μg/500μg

    规格:25μg产品价格:¥860.0
    规格:100μg产品价格:询价
    规格:500μg产品价格:询价
    p16-INK4A (also known as CDKN2A) is a tumor suppressor protein that plays a key role in regulating the cell cycle. It belongs to the INK4 family of cyclin-dependent kinase inhibitors and functions primarily by inhibiting CDK4 and CDK6. These kinases are essential for the phosphorylation of the retinoblastoma (Rb) protein, which is necessary for the transition from the G1 phase to the S phase of the cell cycle. By preventing this phosphorylation, p16^INK4A effectively blocks the cell cycle progression, acting as a brake to prevent uncontrolled cell division. This function is crucial for maintaining genomic stability and preventing tumor formation. Alterations or loss of p16^INK4A expression are commonly associated with various cancers, including melanoma, pancreatic cancer, and head and neck squamous cell carcinoma.

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    图标文献和实验
    该产品被引用文献
    Kim, W.Y. and Sharpless, N.E. (2006) Cell 127, 265-75.
    相关实验
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      for 1 hour with a 1 :1000 dilution of rat IgG2 a anti-mouse kappa chain monoclonal antibody conjugated to horse-radish peroxidase (LO-MK1 , LO/IMEX) reveal with o-phenylenediamine dihydrochloride (OPD) in revelation solution. SOLUTIONS

    • Monoclonal Antibody Production

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    • Monoclonal Antibody Production

        Monoclonal Antibody Production     Mouse Immunization Order 6 six week old Balb/C mice and let the ARC know they are coming. Have your antigen ready for when they arrive. Once they get there earmark the mice and perform

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    文献支持
    Anti-p16-INK4A, clone D25-L, Recombinant Mouse Monoclonal Ab
    ¥860