Anti-ZO-1 Recombinant Rabbit M

ZO-1 (Zonula Occludens-1) is a key protein in the tight junction complex, which plays a crucial role in maintaining cellular barrier function and regulating paracellular transport. It is a member of the MAGUK (membrane-associated guanylate kinase) family and serves as a scaffold protein that links transmembrane tight junction proteins, such as occludin and claudins, to the actin cytoskeleton. ZO-1 is involved in maintaining the integrity of the epithelial and endothelial cell layers, ensuring selective permeability and tight junction formation. It also participates in cell signaling, cell polarity, and inflammation. Dysregulation of ZO-1 expression or function has been implicated in a variety of diseases, including inflammatory bowel disease (IBD), cancer, and vascular permeability disorders. Its role in cell-cell adhesion and barrier function makes it a critical target for understanding both normal physiology and disease mechanisms.