Anti-Lamin A/C Recombinant Rab

Lamin A and Lamin C are closely related proteins that are components of the nuclear lamina, a dense network of fibers located inside the nuclear envelope. They are encoded by the LMNA gene and play a crucial role in maintaining the structural integrity of the nucleus, organizing chromatin, and regulating various nuclear processes such as DNA replication, transcription, and cell division. Lamin A and Lamin C are produced from the same gene through alternative splicing, with Lamin A being the predominant isoform in differentiated cells. Mutations in LMNA can lead to a range of diseases, collectively known as laminopathies, which include conditions like progeria, muscular dystrophy, and lipodystrophy. These diseases are characterized by defects in nuclear structure and function, often resulting in premature aging or other cellular dysfunctions.