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- Hello Bio
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- 2025年12月10日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20°C
- 英文名：
GSK'872
- 供应商：
Hello Bio
- CAS号：
1346546-69-7
- 规格：
10mg///50mg///10mM solution (in 1mL DMSO)
Potent and selective RIP3 inhibitor. Binds to the RIP3 kinase domain (IC50 = 1.3 nM) and inhibits kinase activity with an IC50 of 1.3 nM. Demonstrates >1000-fold selectivity for RIP3 compared with >300 different kinases. Inhibits necroptosis, TLR3-, TNF-α- and virus-induced necrosis. Also induces caspase8-mediated apoptosis in a concentration-dependent manner (at higher concentration such as 3-10 µM).
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文献和实验synthase kinase 3beta as a target for the therapy of shock and inflammation. Shock. 27 , 113–123. 8. Rubinfeld B, Albert I, Porfiri E, Fiol C, Munemitsu S, Polakis P. (1996) Binding of GSK3beta to the APC-beta-catenin complex
, we may find much more references regarding this issue. http://books.google.com/books?id=3mgPzNFjcWAC&pg=PA51&lpg=PA51&dq=gsk+tyrosine+phosphorylation+and+activity&source=bl&ots=x5ueTldpez&sig=CqRFJleXtEBn9OfelhODPAc28xs&hl=en&ei=KerNSu-XGcem8Abm-qmABA&sa=X&oi=book_result&ct
Cell cycle analysis of Escherichia coli cells
: The C+D period is estimated from the initiation age (ai ), the generation time (τ) and the number of generations spanned per cell cycle. Example: 4-origin-cells: 23 % Generation time (τ): 27 min Initiation age (ai ): 5 min
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