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- 技术资料
- 英文名：
C20A4 Human Chondrocyte Cell Line
- 规格：
T25/冻存管
细胞名称：C20A4 Human Chondrocyte Cell Line
货号：SCC041
种属：human
应用：This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation.
质量：
• Each vial contains ≥ 1X10^6 viable cells.
• Cells are tested by PCR and are negative for HPV-16, HPV-18, Hepatitis A, B, C and HIV-1 & 2 viruses.
• Cells are negative for mycoplasma contamination.
• Each lot of cells are genotyped by STR analysis to verify the unique identity of the cell line.
储存及稳定性：Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
其他说明：Concentration: Please refer to lot specific datasheet.
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文献和实验Housmans BAC, Neefjes M, Surtel DAM, Vitík M, Cremers A, van Rhijn LW, van der Kraan PM, van den Akker GGH, Welting TJM. Synovial fluid from end-stage osteoarthritis induces proliferation and fibrosis of articular chondrocytes via MAPK and RhoGTPase signaling. Osteoarthritis Cartilage. 2022 Jun;30(6):862-874. doi: 10.1016/j.joca.2021.12.015. Epub 2022 Feb 15. PMID: 35176481.
Goldring MB. Culture of immortalized chondrocytes and their use as models of chondrocyte function. Methods Mol Med. 2004;100:37-52. doi: 10.1385/1-59259-810-2:037. PMID: 15280586.
Goldring MB, Birkhead JR, Suen LF, Yamin R, Mizuno S, Glowacki J, Arbiser JL, Apperley JF. Interleukin-1 beta-modulated gene expression in immortalized human chondrocytes. J Clin Invest. 1994 Dec;94(6):2307-16. doi: 10.1172/JCI117595. PMID: 7989586; PMCID: PMC330059.
Finger F, Schörle C, Soder S, Zien A, Goldring MB, Aigner T. Phenotypic characterization of human chondrocyte cell line C-20/A4: a comparison between monolayer and alginate suspension culture. Cells Tissues Organs. 2004;178(2):65-77. doi: 10.1159/000081717. PMID: 15604530.
Preparation of Immortalized Human Chondrocyte Cell Lines
primarily toward developing therapeutic strategies that prevent degradation of cartilage matrix, recent work has also focused on promoting cartilage repair. Success of either strategy depends on the development of reliable cell culture models of human origin.
Online Verification of Human Cell Line Identity by STR DNA Typing
The main prerequisition for any research, development, or production programs involving cell lines is whether a cell line is authentic or not. Microsatellites in the human genome harboring short tandem repeat (STR) DNA markers allow
Human Chondrocyte Cultures as Models of Cartilage-Specific Gene Regulation
The mature articular chondrocyte embedded in the cartilage matrix is a resting cell with no detectable mitotic activity and a very low synthetic activity (1 ). The markers of mature articular chondrocytes are type II collagen (COL
