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- 详细信息
- 文献和实验
- 技术资料
- 库存：
100⁺瓶
- 英文名：
Smoothened Agonist(SAG)
- CAS号：
364590-63-6
- 保质期：
1年
- 供应商：
上海睿安生物13611631389
- 保存条件：
2-8°C
- 规格：
5mg/瓶
Sigma货号566660-1mg平滑激动剂(SAG)(Smoothened Agonist)(价格¥4917.30元/支)上海睿安生物13611631389
Sigma货号566660-5mg平滑激动剂(SAG)(Smoothened Agonist)(价格¥13495.34元/瓶)上海睿安生物13611631389
SAG
≥98%(HPLC),solid,smoothened agonist,Calbiochem®
别名:平滑激动剂，SAG
说明
一般描述
一种细胞渗透性Smoothened激动剂，SAG，可通过与Smo七次跨膜螺旋结构域(KD=59nM)相互作用，调节Smo与其下游效应器的偶联。
一种细胞渗透性苯并噻吩化合物，可通过与Smo七次跨膜螺旋结构域(KD=59nM)相互作用，调节Smo与其下游效应器的偶联。显示可诱导Smo内化。显示可诱导刺猬通路激活(NIH 3T3衍生Shh-LIGHT2细胞中的EC50∼3nM)并抵消环巴胺-KAAD(目录号239804)对Smo的抑制。据报道，在低浓度下作为激活剂，在极高浓度下作为抑制剂。
包装:用惰性气体包装
警告：毒性:标准处理(A)
重悬:复溶后，等分并冷冻保存(-20°C)。贮备溶液在-20°C下可稳定保存至多6个月。
其他说明
Wang,J.,et al.2010.Proc.Natl.Acad.Sci.USA.107,9323.
Meloni,A.R.,et al.2006.Mol.Cell.Biol.26,7750.
Chen,W.,et al.2004.Science306,2257.
Chen,J.K.,et al.2002.Proc.Natl.Acad.Sci. USA99,14071.
Frank-Kamenetsky,M.,et al.2002.J.Biol.1,10.
Meloni,A.R.,et al.2006.Mol.Cell.Biol.26,7750.
Chen,W.,et al.2004.Science306,2257.
Chen,J.K.,et al.2002.Proc.Natl.Acad.Sci. USA99,14071.
Frank-Kamenetsky,M.,et al.2002.J.Biol.1,10.
法律信息:CALBIOCHEM is a registered trademark of Merck KGaA,Darmstadt,Germany
同行评审论文(部分文献)
Circular RNAs in Hedgehog Signaling Activation and Hedgehog-Mediated Medulloblastoma Tumors.
Ani Azatyan et al.
Cancers, 13(20) (2021-10-24)
Within the past decade, circular RNAs have largely emerged as novel regulators of human biology, including brain function and cancer development. On the other hand, the Hedgehog pathway has established roles in regulating biological processes, including tumorigenesis. Here, the circular
Stepwise strategy for generating osteoblasts from human pluripotent stem cells under fully defined xeno-free conditions with small-molecule inducers.
Denise Zujur et al.
Regenerative therapy, 14, 19-31 (2020-01-29)
Clinically relevant human induced pluripotent stem cell (hiPSC) derivatives require efficient protocols to differentiate hiPSCs into specific lineages. Here we developed a fully defined xeno-free strategy to direct hiPSCs toward osteoblasts within 21 days. The strategy successfully achieved the osteogenic
Primary cilia-dependent signaling is involved in regulating mesenchymal stem cell proliferation and pluripotency maintenance.
Zhourui Ma et al.
Journal of molecular histology, 51(3), 241-250 (2020-05-14)
Using a large-scale quantitative mesenchymal stem cells (MSCs) membrane proteomics analysis, we identified a large group of ciliary proteins in the MSCs membrane fraction, which prompted us to examine the cilia, intricate organelles that were originally discovered approximately 100 years ago.
Non-canonical Hedgehog signaling regulates spinal cord and muscle regeneration in Xenopus laevis larvae.
Andrew M Hamilton et al.
eLife, 10 (2021-05-07)
Inducing regeneration in injured spinal cord represents one of modern medicine's greatest challenges. Research from a variety of model organisms indicates that Hedgehog (Hh) signaling may be a useful target to drive regeneration. However, the mechanisms of Hh signaling-mediated tissue
Hedgehog signaling pathway regulates gene expression profile of epididymal principal cells through the primary cilium.
Laura Girardet et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(6), 7593-7609 (2020-04-14)
Primary cilia (PC) are organelles that sense and respond to dynamic changes of the extracellular milieu through the regulation of target genes. By using the epididymis as a model system, we determined the contribution of primary cilia in the regulation
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文献和实验该产品被引用文献
Sigma货号566660-1mg平滑激动剂(SAG)(Smoothened Agonist)(价格¥4917.30元/支)上海睿安生物13611631389
Sigma货号566660-5mg平滑激动剂(SAG)(Smoothened Agonist)(价格¥13495.34元/瓶)上海睿安生物13611631389
SAG
≥98%(HPLC),solid,smoothened agonist,Calbiochem®
别名:平滑激动剂，SAG
说明
一般描述
一种细胞渗透性Smoothened激动剂，SAG，可通过与Smo七次跨膜螺旋结构域(KD=59nM)相互作用，调节Smo与其下游效应器的偶联。
一种细胞渗透性苯并噻吩化合物，可通过与Smo七次跨膜螺旋结构域(KD=59nM)相互作用，调节Smo与其下游效应器的偶联。显示可诱导Smo内化。显示可诱导刺猬通路激活(NIH 3T3衍生Shh-LIGHT2细胞中的EC50∼3nM)并抵消环巴胺-KAAD(目录号239804)对Smo的抑制。据报道，在低浓度下作为激活剂，在极高浓度下作为抑制剂。
包装:用惰性气体包装
警告：毒性:标准处理(A)
重悬:复溶后，等分并冷冻保存(-20°C)。贮备溶液在-20°C下可稳定保存至多6个月。
其他说明
Wang,J.,et al.2010.Proc.Natl.Acad.Sci.USA.107,9323.
Meloni,A.R.,et al.2006.Mol.Cell.Biol.26,7750.
Chen,W.,et al.2004.Science306,2257.
Chen,J.K.,et al.2002.Proc.Natl.Acad.Sci. USA99,14071.
Frank-Kamenetsky,M.,et al.2002.J.Biol.1,10.
Meloni,A.R.,et al.2006.Mol.Cell.Biol.26,7750.
Chen,W.,et al.2004.Science306,2257.
Chen,J.K.,et al.2002.Proc.Natl.Acad.Sci. USA99,14071.
Frank-Kamenetsky,M.,et al.2002.J.Biol.1,10.
法律信息:CALBIOCHEM is a registered trademark of Merck KGaA,Darmstadt,Germany
同行评审论文(部分文献)
Circular RNAs in Hedgehog Signaling Activation and Hedgehog-Mediated Medulloblastoma Tumors.
Ani Azatyan et al.
Cancers, 13(20) (2021-10-24)
Within the past decade, circular RNAs have largely emerged as novel regulators of human biology, including brain function and cancer development. On the other hand, the Hedgehog pathway has established roles in regulating biological processes, including tumorigenesis. Here, the circular
Stepwise strategy for generating osteoblasts from human pluripotent stem cells under fully defined xeno-free conditions with small-molecule inducers.
Denise Zujur et al.
Regenerative therapy, 14, 19-31 (2020-01-29)
Clinically relevant human induced pluripotent stem cell (hiPSC) derivatives require efficient protocols to differentiate hiPSCs into specific lineages. Here we developed a fully defined xeno-free strategy to direct hiPSCs toward osteoblasts within 21 days. The strategy successfully achieved the osteogenic
Primary cilia-dependent signaling is involved in regulating mesenchymal stem cell proliferation and pluripotency maintenance.
Zhourui Ma et al.
Journal of molecular histology, 51(3), 241-250 (2020-05-14)
Using a large-scale quantitative mesenchymal stem cells (MSCs) membrane proteomics analysis, we identified a large group of ciliary proteins in the MSCs membrane fraction, which prompted us to examine the cilia, intricate organelles that were originally discovered approximately 100 years ago.
Non-canonical Hedgehog signaling regulates spinal cord and muscle regeneration in Xenopus laevis larvae.
Andrew M Hamilton et al.
eLife, 10 (2021-05-07)
Inducing regeneration in injured spinal cord represents one of modern medicine's greatest challenges. Research from a variety of model organisms indicates that Hedgehog (Hh) signaling may be a useful target to drive regeneration. However, the mechanisms of Hh signaling-mediated tissue
Hedgehog signaling pathway regulates gene expression profile of epididymal principal cells through the primary cilium.
Laura Girardet et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(6), 7593-7609 (2020-04-14)
Primary cilia (PC) are organelles that sense and respond to dynamic changes of the extracellular milieu through the regulation of target genes. By using the epididymis as a model system, we determined the contribution of primary cilia in the regulation
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Sigma货号566660平滑激动剂(SAG)(Smoothened Agonist)上海睿安生物13611631389
￥13495.34
