Adenylyl cyclase type 2 agonis

Agonist-Induced High-Affinity GTP Hydrolysis as an Index of Receptor-Mediated G Protein Activation in Mammalian Brain Membranes

, in which GTP-bound a-subunit is dissociated from py-subunits (Fig. lC), resulting in a modulation of the function of effector molecules such as adenylyl cyclase, phospholipases, and cGMP phosphodiesterase (Fig. 1D ). The a-subunit of G protein has inherent high

Functional Analysis of Human D1 and D5 Dopaminergic G Protein-Coupled Receptors: Lessons from Mutagenesis of a Conserved Serine Residue in the Cytosol

-binding proteins (Gs/olf) leading to activation of adenylyl cyclase and production of intracellular cAMP. D1R and D5R share high level of amino acid identity in transmembrane (TM) regions. Yet these two GPCR subtypes display distinct ligand binding and G

The Measurement of Cyclic AMP Levels in Biological Preparations

of the second group leads to inhibition of adenylyl cyclase and a reduction in AMP generation. Examples of the latter group include α2 -adrenoceptors, A1 adenosine receptors, D2 dopamine receptors, 5-HT1 type receptors, metabotropic glutamate receptors, and μ