SU-DHL-8细胞系

SU-DHL-8细胞SU-DHL-8细胞系SU-DHL-8人B细胞淋巴瘤细胞

Cell line name SU-DHL-8

Synonyms SUDHL8; SUDHL-8; SuDHL 8; Stanford University-Diffuse Histiocytic Lymphoma-8; DHL-8; DHL8

Accession CVCL_2207

Resource Identification Initiative To cite this cell line use: SU-DHL-8 (RRID:CVCL_2207)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: MD Anderson Cell Lines Project.

Population: Caucasian.

Doubling time: ~48-72 hours (DSMZ=ACC-573).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Array-based CGH.

Omics: CNV analysis.

Omics: CRISPR phenotypic screen.

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: miRNA expression profiling.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Omics: Virome analysis using RNAseq.

Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.

Sequence variations

Mutation; HGNC; HGNC:7133; KMT2D; Simple; p.Pro648Thrfs*2 (c.1940dupC) (c.1940_1941insC); ClinVar=VCV000432829; Zygosity=Heterozygous (Cosmic-CLP=1331038; DepMap=ACH-000656).

Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr234Asn (c.700T>A); ClinVar=VCV000376692; Zygosity=Heterozygous (Cosmic-CLP=1331038; DepMap=ACH-000656).

Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg249Gly (c.745A>G); ClinVar=VCV000376654; Zygosity=Heterozygous (Cosmic-CLP=1331038; DepMap=ACH-000656).

Source(s): ATCC=CRL-2961; Cosmic-CLP=1331038; DSMZ=ACC-573; PubMed=25877200

 

Markers:

Amelogenin X

CSF1PO 11,12

D2S1338 17,20

D3S1358 14,15

D5S818 11,13

D7S820 8

D8S1179 13 (PubMed=25877200)

13,18 (DSMZ=ACC-573)

D13S317 11,13

D16S539 12

D18S51 14,19

D19S433 13

D21S11 30,31.2

FGA 25

Penta D 11,12

Penta E 14,17

TH01 6,9

TPOX 8

vWA 15,19

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103

Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Nature 569:503-508(2019)

 

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775

Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Pan-cancer proteomic map of 949 human cell lines.

Cancer Cell 40:835-849.e8(2022)