U-2932细胞系

U-2932细胞U-2932细胞系U-2932人弥漫大B淋巴瘤细胞

Cell line name U-2932

Synonyms U2932

Accession CVCL_1896

Resource Identification Initiative To cite this cell line use: U-2932 (RRID:CVCL_1896)

Comments Part of: LL-100 blood cancer cell line panel.

Part of: MD Anderson Cell Lines Project.

Characteristics: Genetically heterogeneous, consists of 2 subclones (PubMed=27566572).

Doubling time: 48 hours (PubMed=12533045); ~50 hours (DSMZ=ACC-633).

Omics: Array-based CGH.

Omics: Cell surface proteome.

Omics: Deep exome analysis.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Donor information: Originally the patient was suffering from Hodgkin lymphoma.

Derived from site: In situ; Ascites; UBERON=UBERON_0007795.

HLA typing Source: PubMed=26589293

Class I

HLA-A A*01:01,03:01

HLA-B B*08:01,15:01

HLA-C C*03:04,07:01

 

Source: DSMZCellDive=ACC-633

Class I

HLA-A A*01:01:01,03:01:01

HLA-B B*08:01:01,15:01:01

HLA-C C*03:04:01,07:01:01

Class II

HLA-DP DPA1*01:03:01,01:03:01

DPB1*04:01:01,03:01:01

HLA-DQ DQA1*03:01:01,05:01:01

DQB1*02:01:01,03:02:01

HLA-DR DRA*01:01:01,01:02:02

DRB1*03:01:01,04:01:01

Disease Diffuse large B-cell lymphoma activated B-cell type (NCIt: C36081)

Diffuse large B-cell lymphoma (ORDO: Orphanet_544)

PubMed=12533045; DOI=10.1080/1042819021000032917

Amini R.-M., Berglund M., Rosenquist R., von Heideman A., Lagercrantz S., Thunberg U., Bergh J., Sundstrom C., Glimelius B., Enblad G.

A novel B-cell line (U-2932) established from a patient with diffuse large B-cell lymphoma following Hodgkin lymphoma.

Leuk. Lymphoma 43:2179-2189(2002)

 

PubMed=20054396; DOI=10.1038/nature08638; PMCID=PMC2845535

Davis R.E., Ngo V.N., Lenz G., Tolar P., Young R.M., Romesser P.B., Kohlhammer H., Lamy L., Zhao H., Yang Y.-D., Xu W.-H., Shaffer A.L. 3rd, Wright G., Xiao W.-M., Powell J.I., Jiang J.-K., Thomas C.J., Rosenwald A., Ott G., Muller-Hermelink H.-K., Gascoyne R.D., Connors J.M., Johnson N.A., Rimsza L.M., Campo E., Jaffe E.S., Wilson W.H., Delabie J., Smeland E.B., Fisher R.I., Braziel R.M., Tubbs R.R., Cook J.R., Weisenburger D.D., Chan W.-C., Pierce S.K., Staudt L.M.

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma.

Nature 463:88-92(2010)

 

PubMed=23257783; DOI=10.1038/leu.2012.367

Wenzel S.-S., Grau M., Mavis C., Hailfinger S., Wolf A., Madle H., Deeb G., Dorken B., Thome M., Lenz P., Dirnhofer S., Hernandez-Ilizaliturri F.J., Tzankov A., Lenz G.

MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma.

Leukemia 27:1381-1390(2013)

 

PubMed=23292937; DOI=10.1073/pnas.1205299110; PMCID=PMC3557051

Zhang J., Grubor V., Love C.L., Banerjee A., Richards K.L., Mieczkowski P.A., Dunphy C., Choi W.W.-L., Au W.Y., Srivastava G., Lugar P.L., Rizzieri D.A., Lagoo A.S., Bernal-Mizrachi L., Mann K.P., Flowers C.R., Naresh K.N., Evens A.M., Gordon L.I., Czader M.B., Gill J.I., Hsi E.D., Liu Q.-Q., Fan A., Walsh K., Jima D., Smith L.L., Johnson A.J., Byrd J.C., Luftig M.A., Ni T., Zhu J., Chadburn A., Levy S., Dunson D.B., Dave S.S.

Genetic heterogeneity of diffuse large B-cell lymphoma.

Proc. Natl. Acad. Sci. U.S.A. 110:1398-1403(2013)

 

PubMed=23295736; DOI=10.1038/leu.2012.358

Quentmeier H., Amini R.-M., Berglund M., Dirks W.G., Ehrentraut S., Geffers R., MacLeod R.A.F., Nagel S., Romani J., Scherr M., Zaborski M., Drexler H.G.

U-2932: two clones in one cell line, a tool for the study of clonal evolution.

Leukemia 27:1155-1164(2013)

 

PubMed=25485619; DOI=10.1038/nbt.3080

Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.

A comprehensive transcriptional portrait of human cancer cell lines.

Nat. Biotechnol. 33:306-312(2015)

 

PubMed=25894527; DOI=10.1371/journal.pone.0121314; PMCID=PMC4404347

Bausch-Fluck D., Hofmann A., Bock T., Frei A.P., Cerciello F., Jacobs A., Moest H., Omasits U., Gundry R.L., Yoon C., Schiess R., Schmidt A., Mirkowska P., Hartlova A.S., Van Eyk J.E., Bourquin J.-P., Aebersold R., Boheler K.R., Zandstra P.W., Wollscheid B.

A mass spectrometric-derived cell surface protein atlas.

PLoS ONE 10:E0121314-E0121314(2015)

 

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878

Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Genome Med. 7:118.1-118.7(2015)