TOLEDO细胞系

TOLEDO细胞TOLEDO细胞系TOLEDO人弥漫大B细胞淋巴瘤细胞

Cell line name Toledo

Synonyms TOLEDO

Accession CVCL_3611

Resource Identification Initiative To cite this cell line use: Toledo (RRID:CVCL_3611)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: MD Anderson Cell Lines Project.

Population: Caucasian.

Doubling time: ~24-30 hours (ATCC=CRL-2631).

Omics: Array-based CGH.

Omics: CNV analysis.

Omics: Deep exome analysis.

Omics: miRNA expression profiling.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Omics: Virome analysis using RNAseq.

Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.

Cell type: B-cell; CL=CL_0000236.

Sequence variations

Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (DepMap=ACH-000285).

Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu198fs (c.592_596del5); Zygosity=Unspecified (DepMap=ACH-000285).

HLA typing Source: PubMed=26589293

Class I

HLA-A A*24:02,30:02

HLA-B B*18:01,41:01

HLA-C C*12:03,17:01

Genome ancestry Source: PubMed=30894373

 

Origin % genome

African 7.85

Native American 0

East Asian, North 5.12

East Asian, South 0

South Asian 4.69

European, North 17.53

European, South 64.81

Disease Diffuse large B-cell lymphoma germinal center B-cell type (NCIt: C36080)

Diffuse large B-cell lymphoma (ORDO: Orphanet_544)

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell Female

Age at sampling Adult

Category Cancer cell line

STR profile Source(s): ATCC=CRL-2631; PubMed=25877200

 

Markers:

Amelogenin X

CSF1PO 12

D2S1338 19,23

D3S1358 16,18

D5S818 10,12

D7S820 9,10

D8S1179 13

D13S317 11

D16S539 9

D18S51 12

D19S433 15,15.2

D21S11 28,32.2

FGA 19,22

Penta D 11,13

Penta E 10,12

TH01 8,9.3

TPOX 8,11

vWA 16,17

 

Run an STR similarity search on this cell line

PubMed=10485273; DOI=10.1111/j.1600-0609.1999.tb01766.x

Gabay C., Ben-Bassat H., Schlesinger M., Laskov R.

Somatic mutations and intraclonal variations in the rearranged Vkappa genes of B-non-Hodgkin's lymphoma cell lines.

Eur. J. Haematol. 63:180-191(1999)

 

PubMed=19278952; DOI=10.1182/blood-2009-01-202028; PMCID=PMC3401058

Li C., Kim S.-W., Rai D., Bolla A.R., Adhvaryu S., Kinney M.C., Robetorye R.S., Aguiar R.C.T.

Copy number abnormalities, MYC activity, and the genetic fingerprint of normal B cells mechanistically define the microRNA profile of diffuse large B-cell lymphoma.

Blood 113:6681-6690(2009)

 

PubMed=19358282; DOI=10.1002/ijc.24351

Inagaki A., Ishida T., Yano H., Ishii T., Kusumoto S., Ito A., Ri M., Mori F., Ding J.-M., Komatsu H., Iida S., Ueda R.

Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC.

Int. J. Cancer 125:212-221(2009)

 

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662

Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Cancer Res. 70:2158-2164(2010)

 

PubMed=20628145; DOI=10.1182/blood-2010-05-282780; PMCID=PMC2995356

Green M.R., Monti S., Rodig S.J., Juszczynski P., Currie T., O'Donnell E., Chapuy B., Takeyama K., Neuberg D., Golub T.R., Kutok J.L., Shipp M.A.

Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.

Blood 116:3268-3277(2010)

 

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027

Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Nature 483:603-607(2012)

 

PubMed=23292937; DOI=10.1073/pnas.1205299110; PMCID=PMC3557051

Zhang J., Grubor V., Love C.L., Banerjee A., Richards K.L., Mieczkowski P.A., Dunphy C., Choi W.W.-L., Au W.Y., Srivastava G., Lugar P.L., Rizzieri D.A., Lagoo A.S., Bernal-Mizrachi L., Mann K.P., Flowers C.R., Naresh K.N., Evens A.M., Gordon L.I., Czader M.B., Gill J.I., Hsi E.D., Liu Q.-Q., Fan A., Walsh K., Jima D., Smith L.L., Johnson A.J., Byrd J.C., Luftig M.A., Ni T., Zhu J., Chadburn A., Levy S., Dunson D.B., Dave S.S.

Genetic heterogeneity of diffuse large B-cell lymphoma.

Proc. Natl. Acad. Sci. U.S.A. 110:1398-1403(2013)