SW403细胞

SW403/SW403细胞系/SW403细胞株/SW403结肠癌细胞

Cell line name SW403

Synonyms SW-403; SW 403

Accession CVCL_0545

Resource Identification Initiative To cite this cell line use: SW403 (RRID:CVCL_0545)

Comments Part of: AstraZeneca Colorectal cell line (AZCL) panel.

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: KuDOS 95 cell line panel.

Part of: NCI RAS program mutant KRAS cell line panel.

From: Scott and White Clinic; Temple; USA.

Population: Caucasian.

Doubling time: 79 hours (Note=At 31th passage) (PubMed=1000501); 38.19 hours (PubMed=25944804); ~40-50 hours (DSMZ=ACC-294).

Microsatellite instability: Stable (MSS) (PubMed=24755471; PubMed=25926053; PubMed=28683746; Sanger).

Omics: Deep exome analysis.

Omics: Deep proteome analysis.

Omics: Deep quantitative proteome analysis.

Omics: miRNA expression profiling.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: In situ; Colon; UBERON=UBERON_0001155.

Sequence variations

Mutation; HGNC; 583; APC; Simple; p.Asn125Lys (c.375T>G); Zygosity=Heterozygous (PubMed=24755471; PubMed=28179481; Cosmic-CLP=910908; DepMap=ACH-000820).

Mutation; HGNC; 583; APC; Simple; p.Ser1198Glnfs*67 (c.3591delC); Zygosity=Heterozygous (PubMed=24755471; PubMed=28179481; Cosmic-CLP=910908; DepMap=ACH-000820).

Mutation; HGNC; 583; APC; Simple; p.Ser1278Ter (c.3833C>A); Zygosity=Heterozygous (PubMed=24755471; PubMed=28179481; Cosmic-CLP=910908; DepMap=ACH-000820).

Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Heterozygous (PubMed=12068308; PubMed=20570890; PubMed=24755471; PubMed=28683746; Cosmic-CLP=910908; DepMap=ACH-000820).

Mutation; HGNC; 8975; PIK3CA; Simple; p.Gln546Lys (c.1636C>A); ClinVar=VCV000013657; Zygosity=Heterozygous (PubMed=24755471; Cosmic-CLP=910908; DepMap=ACH-000820).

Mutation; HGNC; 11998; TP53; Simple; p.Glu51Ter (c.151G>T); ClinVar=VCV000568781; Zygosity=Homozygous (PubMed=16418264; PubMed=28683746; Cosmic-CLP=910908; DepMap=ACH-000820).

HLA typing Source: PubMed=8464898

Class I

HLA-A A*02,03

 

Source: PubMed=26589293

Class I

HLA-A A*02:05,03:01

HLA-B B*07:02,49:01

HLA-C C*07:02,07:02

Genome ancestry Source: PubMed=30894373

 

Origin % genome

African 0.6

Native American 0.4

East Asian, North 0.5

East Asian, South 0

South Asian 3.26

European, North 62.34

European, South 32.9

Disease Colon adenocarcinoma (NCIt: C4349)

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell Female

Age at sampling 51Y

Category Cancer cell line

STR profile Source(s): ATCC=CCL-230; CLS=300350; DSMZ=ACC-294; ECACC=87071008; KCLB=10230; PubMed=25877200; PubMed=25926053

 

Markers:

Amelogenin X

CSF1PO 10,13

D2S1338 24

D3S1358 15

D5S818 11

D7S820 8,9

D8S1179 11 (CLS=300350)

11,14 (ATCC=CCL-230; PubMed=25877200)

12 (DSMZ=ACC-294)

D13S317 13

D16S539 10,12

D18S51 17

D19S433 16,18.2 (ATCC=CCL-230)

17 (DSMZ=ACC-294)

D21S11 28,29

FGA 19

Penta D 9

Penta E 5

TH01 6

TPOX 8,9

vWA 14,18

 

Run an STR similarity search on this cell line

PubMed=1000501

Leibovitz A., Stinson J.C., McCombs W.B. 3rd, McCoy C.E., Mazur K.C., Mabry N.D.

Classification of human colorectal adenocarcinoma cell lines.

Cancer Res. 36:4562-4569(1976)

 

PubMed=327080; DOI=10.1093/jnci/59.1.221

Fogh J., Fogh J.M., Orfeo T.

One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.

J. Natl. Cancer Inst. 59:221-226(1977)

 

PubMed=924690; DOI=10.1002/ijc.2910200505

Kerbel R.S., Pross H.F., Leibovitz A.

Analysis of established human carcinoma cell lines for lymphoreticular-associated membrane receptors.

Int. J. Cancer 20:673-679(1977)

 

PubMed=286328; DOI=10.1073/pnas.76.3.1438; PMCID=PMC383267

Herlyn M., Steplewski Z., Herlyn D., Koprowski H.

Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies.

Proc. Natl. Acad. Sci. U.S.A. 76:1438-1442(1979)

 

PubMed=7104989; DOI=10.1016/0165-4608(82)90076-0

Chen T.-R., Hay R.J., Macy M.L.

Karyotype consistency in human colorectal carcinoma cell lines established in vitro.

Cancer Genet. Cytogenet. 6:93-117(1982)

 

PubMed=6220172

Dracopoli N.C., Fogh J.

Polymorphic enzyme analysis of cultured human tumor cell lines.

J. Natl. Cancer Inst. 70:469-476(1983)

 

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720

Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.

Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.

Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

 

PubMed=3518877; DOI=10.3109/07357908609038260

Fogh J.

Human tumor lines for cancer research.

Cancer Invest. 4:157-184(1986)

 

PubMed=8464898; DOI=10.1073/pnas.90.7.2842; PMCID=PMC46192

Browning M.J., Krausa P., Rowan A.J., Bicknell D.C., Bodmer J.G., Bodmer W.F.

Tissue typing the HLA-A locus from genomic DNA by sequence-specific PCR: comparison of HLA genotype and surface expression on colorectal tumor cell lines.

Proc. Natl. Acad. Sci. U.S.A. 90:2842-2845(1993)

 

PubMed=7972006; DOI=10.1073/pnas.91.23.11045; PMCID=PMC45163

Okamoto A., Demetrick D.J., Spillare E.A., Hagiwara K., Hussain S.P., Bennett W.P., Forrester K., Gerwin B.I., Serrano M., Beach D.H., Harris C.C.

Mutations and altered expression of p16INK4 in human cancer.

Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994)

 

PubMed=9294210; DOI=10.1073/pnas.94.19.10330; PMCID=PMC23362

Ilyas M., Tomlinson I.P.M., Rowan A.J., Pignatelli M., Bodmer W.F.

Beta-catenin mutations in cell lines established from human colorectal cancers.

Proc. Natl. Acad. Sci. U.S.A. 94:10330-10334(1997)

 

PubMed=10737795; DOI=10.1073/pnas.97.7.3352; PMCID=PMC16243

Rowan A.J., Lamlum H., Ilyas M., Wheeler J., Straub J., Papadopoulou A., Bicknell D.C., Bodmer W.F., Tomlinson I.P.M.

APC mutations in sporadic colorectal tumors: a mutational 'hotspot' and interdependence of the 'two hits'.

Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000)

 

PubMed=11226274; DOI=10.1073/pnas.041603298; PMCID=PMC30173

Abdel-Rahman W.M., Katsura K., Rens W., Gorman P.A., Sheer D., Bicknell D.C., Bodmer W.F., Arends M.J., Wyllie A.H., Edwards P.A.W.

Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement.

Proc. Natl. Acad. Sci. U.S.A. 98:2538-2543(2001)