NCI-H226细胞

NCI-H226/NCI-H226细胞系/NCI-H226细胞株/NCI-H226人肺鳞癌细胞

Cell line name NCI-H226

Synonyms NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226

Accession CVCL_1544

Resource Identification Initiative To cite this cell line use: NCI-H226 (RRID:CVCL_1544)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: JFCR39 cancer cell line panel.

Part of: KuDOS 95 cell line panel.

Part of: MD Anderson Cell Lines Project.

Part of: NCI-60 cancer cell line panel.

Part of: NCI-7 clinical proteomics reference material cell line panel.

Population: Caucasian.

Doubling time: 43 hours (PubMed=9488600); 52 hours (PubMed=29681454); 61 hours (NCI-DTP=NCI-H226).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Array-based CGH.

Omics: CNV analysis.

Omics: CRISPR phenotypic screen.

Omics: Deep exome analysis.

Omics: Deep proteome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: Fluorescence phenotype profiling.

Omics: lncRNA expression profiling.

Omics: Metabolome analysis.

Omics: Protein expression by reverse-phase protein arrays.

Omics: Proteome analysis by 2D-DE/MS.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Caution: Indicated to have a TP53 p.Arg158Leu (c.473G>T) mutation according to PubMed=1311061, but no TP53 mutation detected according to PubMed=20557307, CCLE and Cosmic-CLP.

Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.

PubMed=1568228

Metcalf R.A., Welsh J.A., Bennett W.P., Seddon M.B., Lehman T.A., Pelin-Enlund K., Linnainmaa K., Tammilehto L., Mattson K., Gerwin B.I., Harris C.C.

p53 and Kirsten-ras mutations in human mesothelioma cell lines.

Cancer Res. 52:2610-2615(1992)

 

PubMed=8806092; DOI=10.1002/jcb.240630505

Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.

NCI-Navy Medical Oncology Branch cell line data base.

J. Cell. Biochem. Suppl. 24:32-91(1996)

 

PubMed=8806101; DOI=10.1002/jcb.240630514

Lokshin A.E., Levitt M.L.

Effect of suramin on squamous differentiation and apoptosis in three human non-small-cell lung cancer cell lines.

J. Cell. Biochem. Suppl. 24:186-197(1996)

 

PubMed=8956792; DOI=10.1038/bjc.1996.629; PMCID=PMC2077222

Fang K.

An enhanced and sensitive autocrine stimulation by transforming growth factor-alpha is acquired in the brain metastatic variant of a human non-small-cell lung cancer cell line.

Br. J. Cancer 74:1776-1782(1996)

 

PubMed=9488600; DOI=10.1007/s002800050744

Ma J.-G., Maliepaard M., Nooter K., Boersma A.W.M., Verweij J., Stoter G., Schellens J.H.M.

Synergistic cytotoxicity of cisplatin and topotecan or SN-38 in a panel of eight solid-tumor cell lines in vitro.

Cancer Chemother. Pharmacol. 41:307-316(1998)

 

PubMed=9649128; DOI=10.1038/bjc.1998.361; PMCID=PMC2150402

Yi S., Chen J.-R., Viallet J., Schwall R.H., Nakamura T., Tsao M.-S.

Paracrine effects of hepatocyte growth factor/scatter factor on non-small-cell lung carcinoma cell lines.

Br. J. Cancer 77:2162-2170(1998)

 

PubMed=10700174; DOI=10.1038/73432

Ross D.T., Scherf U., Eisen M.B., Perou C.M., Rees C., Spellman P.T., Iyer V.R., Jeffrey S.S., van de Rijn M., Waltham M.C., Pergamenschikov A., Lee J.C.F., Lashkari D., Shalon D., Myers T.G., Weinstein J.N., Botstein D., Brown P.O.

Systematic variation in gene expression patterns in human cancer cell lines.

Nat. Genet. 24:227-235(2000)

 

PubMed=11030152; DOI=10.1038/sj.onc.1203815

Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.

Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.

Oncogene 19:4632-4639(2000)

 

PubMed=11369051; DOI=10.1016/S0165-4608(00)00363-0

Luk C., Tsao M.-S., Bayani J., Shepherd F.A., Squire J.A.

Molecular cytogenetic analysis of non-small cell lung carcinoma by spectral karyotyping and comparative genomic hybridization.

Cancer Genet. Cytogenet. 125:87-99(2001)