H9细胞

H9/H9细胞系/H9细胞株/H9人T淋巴瘤细胞

Cell line name H9

Synonyms HT clone H9; HT(H9); H 9; H-9

Accession CVCL_1240

Resource Identification Initiative To cite this cell line use: H9 (RRID:CVCL_1240)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Population: Caucasian.

Virology: Permissive for HIV-1 replication. Is accordingly used to isolate and propagate HIV-1 from the blood of patients with AIDS.

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Anecdotal: For a number of years it was not known that H9 used by Gallo's lab to isolate HIV-1 (HTLV-III) was in fact a clone of Hut 78 from Minna's lab (PubMed=2567177). This created a controversy between the labs of Minna and Gallo (PubMed=2193399).

Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.

Cell type: T-cell; CL=CL_0000084.

PubMed=1460674; DOI=10.1093/jnci/84.24.1922

Chen T.-R.

Karyotypic derivation of H9 cell line expressin

 

PubMed=8320746; DOI=10.1093/jnci/85.14.1168

Bunn P.A. Jr., Whang-Peng J., Gazdar A.F., Minna J.D., Carney D.N.

Karyotypic derivation of H9 cell line.

J. Natl. Cancer Inst. 85:1168-1169(1993)

 

PubMed=8127147

Heyman M., Grander D., Brondum-Nielsen K., Cederblad B., Liu Y., Xu B., Einhorn S.

Interferon system defects in malignant T-cells.

Leukemia 8:425-434(1994)

 

PubMed=7707540; DOI=10.1128/JVI.69.5.3117-3124.1995; PMCID=PMC189013

Arthur L.O., Bess J.W. Jr., Urban R.G., Strominger J.L., Morton W.R., Mann D.L., Henderson L.E., Benveniste R.E.

Macaques immunized with HLA-D

 

PubMed=8641406; DOI=10.1111/j.1600-0609.1996.tb00721.x

Borgonovo-Brandter L., Heyman M., Rasool O., Liu Y., Grander D., Einhorn S.

p16INK4/p15INK4B gene inactivation is a frequent event in malignant T-cell lines.

Eur. J. Haematol. 56:313-318(1996)

 

PubMed=17170727; DOI=10.1038/sj.leu.2404486

Sandberg Y., Verhaaf B., van Gastel-Mol E.J., Wolvers-Tettero I.L.M., De Vos J., MacLeod R.A.F., Noordzij J.G., Dik W.A., van Dongen J.J.M., Langerak A.W.

Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.

Leukemia 21:230-237(2007)

 

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113

Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

 

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469

Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mi., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

A landscape of pharmacogenomic interactions in cancer.

Cell 166:740-754(2016)

 

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Cancer Res. 79:1263-1273(2019)

 

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775

Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Pan-cancer proteomic map of 949 human cell lines.

Cancer Cell 40:835-849.e8(2022)