A172细胞

【A172】A172细胞/A172细胞/A172人胶质母细胞瘤细胞Cell line name A-172

Synonyms A172; A 172; A-172 MG; A-172MG

Accession CVCL_0131

Resource Identification Initiative To cite this cell line use: A-172 (RRID:CVCL_0131)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).

Part of: PTEN genetic alteration cell panel (ATCC TCP-1030).

Population: Caucasian.

Doubling time: 44 hours (PubMed=9842975); 40 hours (PubMed=25984343); 33-48 hours (PubMed=30188626); ~45 hours (Note=Lot 021999), ~30 hours (Note=Lot 06092006), ~42 hours (Note=Lot 06262015), ~26 hours (Note=Lot 12192018) (JCRB=JCRB0228).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Array-based CGH.

Omics: CNV analysis.

Omics: CRISPR phenotypic screen.

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: shRNA library screening.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: In situ; Brain; UBERON=UBERON_0000955.

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PubMed=16697959; DOI=10.1016/j.ccr.2006.03.030

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IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas.

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Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

 

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662

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A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Cancer Res. 70:2158-2164(2010)

 

PubMed=21406405; DOI=10.1158/0008-5472.CAN-10-3112

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MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-beta signaling pathway in human glioblastoma.

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PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878

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Genome Med. 7:118.1-118.7(2015)

 

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469

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PubMed=30188626; DOI=10.1134/S1990519X16050072

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An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Cancer Res. 79:1263-1273(2019)

 

PubMed=30971826; DOI=10.1038/s41586-019-1103-9

Behan F.M., Iorio F., Picco G., Goncalves E., Beaver C.M., Migliardi G., Santos R., Rao Y., Sassi F., Pinnelli M., Ansari R., Harper S., Jackson D.A., McRae R., Pooley R., Wilkinson P., van der Meer D.J., Dow D., Buser-Doepner C.A., Bertotti A., Trusolino L., Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Nature 568:511-516(2019)

 

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103

Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Nature 569:503-508(2019)

 

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254

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Cell 180:387-402.e16(2020)

 

PubMed=34036375; DOI=10.3892/mmr.2021.12172; PMCID=PMC8170197

Cao Y.-Q., Chai W.-Y., Wang Y.-G., Tang D., Shao D.-C., Song H., Long J.

lncRNA TUG1 inhibits the cancer stem cell-like properties of temozolomide-resistant glioma cells by interacting with EZH2.

Mol. Med. Rep. 24:533.1-533.10(2021)

 

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775

Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Pan-cancer proteomic map of 949 human cell lines.

Cancer Cell 40:835-849.e8(2022)