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总谷胱甘肽过氧化物酶检测试剂盒(NADPH法) (Total Glutathione Peroxidase Assay Kit with NADPH)是一种简单易行的通过紫外比色来检测细胞、组织或其它样品中谷胱甘肽过氧化物酶(Glutathione peroxidase, GPx)活性的试剂盒。
绝大部分细胞内的谷胱甘肽过氧化物酶都是含硒的，且硒为该酶的活性中心组成部分。细胞内也有很少量的不含硒的谷胱甘肽过氧化物酶存在。本试剂盒可以定量检测出最常见的含硒的谷胱甘肽过氧化物酶和少量不含硒的谷胱甘肽过氧化物酶的总量。
本试剂盒和谷胱甘肽过氧化物酶检测试剂盒(S0056)配合使用，可以定量检测出样品中不含硒的谷胱甘肽过氧化物酶。
谷胱甘肽过氧化物酶可以清除活细胞内的过氧化物，在保护细胞免受自由基损伤过程中起着关键作用。细胞内的脂类容易和自由基发生反应，产生脂类过氧化物。谷胱甘肽过氧化物酶可以利用还原型谷胱甘肽(GSH)还原脂类过氧化物，从而消除自由基的毒害作用。谷胱甘肽过氧化物酶几乎在所有组织中都有分布。在一些病理状况下谷胱甘肽过氧化物酶的活力会发生明显上调或下调。
谷胱甘肽过氧化物酶可以利用还原型谷胱甘肽(GSH)催化过氧化氢以及许多有机过氧化物，产生水或有机醇。但以过氧化氢为底物进行检测会受同样可以分解过氧化氢的过氧化氢酶(Catalase)的影响，因为过氧化氢酶的酶活性会干扰谷胱甘肽过氧化物酶的测定。本试剂盒利用了一种间接测定的方法。谷胱甘肽过氧化物酶(GPx)可以催化GSH产生G SSG，而谷胱甘肽还原酶可以利用NADPH催化G SSG产生GSH，通过检测NADPH的减少量就可以计算出谷胱甘肽过氧化物酶的活力水平。在上述反应中谷胱甘肽过氧化物酶是整个反应体系的限速步骤，因此NADPH的减少量和谷胱甘肽过氧化物酶的活力线性相关。
本试剂盒利用了如下的反应原理，GPx为谷胱甘肽过氧化物酶(Glutathione peroxidase)，GR为谷胱甘肽还原酶(Glutathione reductase)，R-OOH为过氧化物。
本试剂盒提供的有机过氧化物试剂(Cum-OOH)在没有谷胱甘肽过氧化物酶存在的情况下不会和GSH产生反应，也不会被细胞内的过氧化氢酶催化而分解。因而可以较为特异地检测出谷胱甘肽过氧化物酶的活力。
有机过氧化物试剂(Cum-OOH)不仅可以作为含硒的谷胱甘肽过氧化物酶的底物，也可作为不含硒的谷胱甘肽过氧化物酶的底物，因此本试剂盒可以定量检测总谷胱甘肽过氧化物酶。
本试剂盒可检测组织匀浆产物、细胞裂解产物等样品中谷胱甘肽过氧化物酶的活性。一个试剂盒可进行100次检测。
包装清单：
| 产品编号 | 产品名称 | 包装 |
| S0058-1 | 样品匀浆液 | 100ml |
| S0058-2 | 谷胱甘肽过氧化物酶检测缓冲液 | 50ml |
| S0058-3 | 谷胱甘肽还原酶 | 100µl |
| S0058-4 | NADPH | 11.5mg |
| S0058-5 | 还原型谷胱甘肽(GSH) | 10mg |
| S0058-6 | 过氧化物试剂(Cum-OOH) | 200µl |
| — | 说明书 | 1份 |
保存条件：
-20℃保存，一年有效。NADPH溶解后宜适当分装并-70℃保存，4℃可以保存一天，-20℃保存一周后NADPH会降解10%以上。GSH在配制成溶液后，适当分装后-20℃保存。
注意事项：
本试剂盒检测时涉及到氧化还原反应，因此所有氧化剂或还原剂都会干扰本试剂盒的测定。如果在样品中的还原剂无法避免，例如DTT、巯基乙醇等，则这些还原剂的总浓度至少低于0.1mM。0.15mM的DTT可以抑制40%的酶活力。
常用的Triton X-100、Tween-20等去垢剂都含有较高水平的过氧化物，会影响本试剂盒的测定。如果必须使用这些去垢剂，最好使用纯度较高并注明含较低过氧化物的去垢剂。
加入过氧化物试剂溶液后的第一次读数，例如0分钟时A340读值不宜低于1。如果读数低于1，说明样品中的GPx活力太高，或者样品中本身的G SSG含量太高，需要将样品适当稀释或者减少样品的用量，否则反应很快就进入平台期，无法获取正常的检测数据。样品可以立即测定，也可以-70℃冻存待以后测定。
一定要严格控制反应时的温度为25℃，否则会引起较多误差。
NADPH不太稳定，要严格按照后续说明操作，谨防失活。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
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1. Guanning Huang, Jiankun Zang, Lizhen He, Huili Zhu, Jiarun Huang, Zhongwen Yuan, Tianfeng Chen, Anding Xu
.
Bioactive Nanoenzyme Reverses Oxidative Damage and Endoplasmic Reticulum Stress in Neurons under Ischemic Stroke
ACS Nano. 2022 Jan 25;16(1):431-452. doi: 10.1021/acsnano.1c07205. (IF 14.588)
2. Shaofang Zhang, Yonghui Li, Si Sun, Ling Liu, Xiaoyu Mu, Shuhu Liu, Menglu Jiao, Xinzhu Chen, Ke Chen, Huizhen Ma, Tuo Li, Xiaoyu Liu, Hao Wang, Jianning Zhang, Jiang Yang, Xiao-Dong Zhang
.
Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma
Nat Commun. 2022 Aug 12;13(1):4744. doi: 10.1038/s41467-022-32411-z. (IF 12.121)
3. Chen M, Zheng J, Liu G, Xu E, Wang J, Fuqua BK, Vulpe CD, Anderson GJ, Chen H
.
Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux.
Redox Biol. 2018 Jul;17:432-439. (IF 9.986)
4. Lu MC, Zhao J, Liu YT, Liu T, Tao MM, You QD, Jiang ZY
.
CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation.
Redox Biol. 2019 Sep 26:101266. (IF 9.986)
5. Guang-Hui Chen, Chang-Chun Song, Tao Zhao, Christer Hogstrand, Xiao-Lei Wei, Wu-Hong Lv, Yu-Feng Song, Zhi Luo
.
Mitochondria-Dependent Oxidative Stress Mediates ZnO Nanoparticle (ZnO NP)-Induced Mitophagy and Lipotoxicity in Freshwater Teleost Fish
Environ Sci Technol. 2022 Feb 15;56(4):2407-2420. doi: 10.1021/acs.est.1c07198. (IF 7.864)
6. Xiliang Du, Chiara Di Malta, Zhiyuan Fang, Taiyu Shen, Xiaodi Niu, Meng Chen, Bo Jin, Hao Yu, Lin Lei, Wenwen Gao, Yuxiang Song, Zhe Wang, Chuang Xu, Zhijun Cao, Guowen Liu, Xinwei Li
.
Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy-lysosomal pathway
Acta Pharm Sin B. 2022 Jun;12(6):2869-2886. doi: 10.1016/j.apsb.2021.12.012. (IF 7.097)
7. Songge Deng, Yizhao Wu, Hanqi Duan, Jo-Anne E Cavanagh, Xiuhong Wang, Jiangping Qiu, Yinsheng Li
.
Toxicity assessment of earthworm exposed to arsenate using oxidative stress and burrowing behavior responses and an integrated biomarker index
Sci Total Environ. 2021 Dec 15;800:149479. doi: 10.1016/j.scitotenv.2021.149479. (IF 6.551)
8. Zhai X, Zhang C, Zhao G, Stoll S, Ren F, Leng X.
.
Antioxidant capacities of the selenium nanoparticles stabilized by chitosan.
J NANOBIOTECHNOL. 2017 Jan 5;15(1):4. (IF 6.518)
9. Deng J, Liu Q, Zhang Q, Zhang C, Liu D, Fan D, Yang H
.
Comparative study on composition, physicochemical and antioxidant characteristics of different varieties of kiwifruit seed oil in China.
Food Chem. 2018 Oct 30;264:411-418. (IF 6.306)
10. Lu MC, Jiao Q, Liu T, Tan SJ, Zhou HS, You QD, Jiang ZY.
.
Discovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potency.
Eur J Med Chem. 2018 Jan 1;143:1578-1589. (IF 5.572)
11. Yao C, Li G, Qian Y, Cai M, Yin H, Xiao L, Tang W, Guo F, Shi B.
.
Protection of Pentoxifylline against Testis Injury Induced by Intermittent Hypobaric Hypoxia.
Oxid Med Cell Longev. 2016;2016:3406802. (IF 5.076)
12. Zhang Y, Li Q, Fang M, Ma Y, Liu N, Yan X, Zhou J, Li F
.
The Kidney Injury Induced by Short-Term PM2.5 Exposure and the Prophylactic Treatment of Essential Oils in BALB/c Mice.
Oxid Med Cell Longev. 2018 Jul 29;2018:9098627. (IF 5.076)
13. Yu HF, Duan CC, Yang ZQ, Wang YS, Yue ZP, Guo B
.
HB-EGF Ameliorates Oxidative Stress-Mediated Uterine Decidualization Damage.
Oxid Med Cell Longev. 2019 Dec 2 2019:6170936. (IF 5.076)
14. Lei Zhang, Cundong Fan, Hua-Chen Jiao, Qian Zhang, Yue-Hua Jiang, Jie Cui, Yang Liu, Yong-Hao Jiang, Juan Zhang, Meng-Qi Yang, Yan Li, Yi-Tao Xue
.
Calycosin Alleviates Doxorubicin-Induced Cardiotoxicity and Pyroptosis by Inhibiting NLRP3 Inflammasome Activation
Oxid Med Cell Longev. 2022 Jan 5:2022:1733834. doi: 10.1155/2022/1733834. (IF 5.076)
15. Binbing Liu, Yang Tian, Yuchen Li, Pei Wu, Yongzhi Zhang, Jiaolin Zheng, Huaizhang Shi
.
ACEA Attenuates Oxidative Stress by Promoting Mitophagy via CB1R/Nrf1/PINK1 Pathway after Subarachnoid Hemorrhage in Rats
Oxid Med Cell Longev. 2022 Feb 24:2022:1024279. doi: 10.1155/2022/1024279. (IF 5.076)
16. Mengrong Miao, Yangyang Wang, Shuang Zeng, Yaqian Han, Ruilou Zhu, Pengfei Yu, Yitian Yang, Ningning Fu, Ningning Li, Mingyang Sun, Jiaqiang Zhang
.
Identification and Validation of Ferroptosis-Related Genes in Sevoflurane-Induced Hippocampal Neurotoxicity
Oxid Med Cell Longev. 2022 Oct 4:2022:4435161. doi: 10.1155/2022/4435161. (IF 5.076)
17. Xiao-Long W, Chuan-Ping Y, Kai X, Ou-Jv Q.
.
Selenoprotein W depletion in vitro might indicate that its main function is not as an antioxidative enzyme.
BIOCHEMISTRY-MOSCOW+. 2010;75(2):201-7. (IF 1.978)
18. Wang J, Sun P, Bao Y, Liu J, An L.
.
Cytotoxicity of single-walled carbon nanotubes on PC12 cells.
Toxicol In Vitro. 2011 Feb;25(1):242-50. (IF 2.959)
19. Chen J, Xiao S, Deng Y, Du X, Yu Z.
.
Cloning of a novel glutathione S-transferase 3 (GST3) gene and expressionanalysis in pearl oyster,Pinctada martensii.
FISH SHELLFISH IMMUN. 2011 Dec;31(6):823-30. (IF 3.298)
20. Shi H, Wang Y, Cheng Z, Ye T, Chan Z.
.
Analysis of natural variation in bermudagrass (Cynodon dactylon) reveals physiological responses underlyingdrought tolerance.
PLoS One. 2012;7(12):e53422. (IF 2.74)
21. Wang J, Sun P, Bao Y, Dou B, Song D, Li Y.
.
Vitamin E renders protection to PC12 cells against oxidative damage and apoptosis induced bysingle-walled carbon nanotubes.
Toxicol In Vitro. 2012 Feb;26(1):32-41. (IF 2.959)
22. Qian Y, Guan T, Huang M, Cao L, Li Y, Cheng H, Jin H, Yu D.
.
Neuroprotection by the soy isoflavone, genistein, via inhibition of mitochondria-dependentapoptosis pathways and reactive oxygen induced-NF-κB activation in a cerebral ischemia mouse model.
Neurochem Int. 2012 Jun;60(8):759-67. (IF 3.881)
23. Zhao J, Xu S, Song F, Nian L, Zhou X, Wang S.
.
2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside protects human umbilical vein endothelial cells against lysophosphatidylcholine-induced apoptosis by upregulating superoxide dismutase and glutathione peroxidase.
IUBMB Life. 2014 Oct;66(10):711-22. (IF 3.244)
24. Li C, Shi L, Chen D, Ren A, Gao T, Zhao M.
.
Functional analysis of the role of glutathione peroxidase (GPx) in the ROS signaling pathway, hyphal branching and the regulation of ganoderic acid biosynthesis in Ganoderma lucidum.
Fungal Genet Biol. 2015 Sep;82:168-80. (IF 3.071)
25. Sun Y, Xiu C, Liu W, Tao Y, Wang J, Qu YI.
.
Grape seed proanthocyanidin extract protects the retina against early diabetic injury by activating the Nrf2pathway.
Exp Ther Med. 2016 Apr;11(4):1253-1258. (IF 1.785)
26. Liu Q, Xu C, Ji G, Liu H, Mo Y, Tollerud DJ, Gu A, Zhang Q.
.
Sublethal effects of zinc oxide nanoparticles on male reproductive cells.
Toxicol In Vitro. 2016 Sep;35:131-8. (IF 2.959)
27. Han X, Xue X, Zhao Y, Li Y, Liu W, Zhang J, Fan S.
.
Rutin-Enriched Extract from Coriandrum sativum L. Ameliorates Ionizing Radiation-InducedHematopoietic Injury.
Int J Mol Sci. 2017 Apr 29;18(5). pii: E942. (IF 4.556)
28. Guo J, Xu B, Han Q, Zhou H, Xia Y, Gong C, Dai X, Li Z, Wu G.
.
Ferroptosis:A Novel Anti-Tumor Action for Cisplatin.
Cancer Res Treat. 2017 May 10. (IF 3.761)
29. Zhu Z, Ren Z, Fan X, Pan Y, Lv S, Pan C, Lei A, Zeng W.
.
Cysteine protects rabbit spermatozoa against reactive oxygen species-induced damages.
PLoS One. 2017 Jul 10;12(7):e0181110. (IF 2.74)
30. He JH, Yan M, Zuo H, Niu S, Yuan J, Weng SP, He J, Xu X.
.
High reduced/oxidized glutathione ratio in infectious spleen and kidney necrosis virus-infectedcells contributes to degradation of VP08R multimers.
Vet Microbiol. 2017 Aug;207:19-24. (IF 3.03)
31. Zhu Z, Fan X, Lv Y, Lin Y, Wu, Zeng W.
.
Glutamine protects rabbit spermatozoa against oxidative stress via glutathione synthesis during cryopreservation.
REPROD FERT DEVELOP. 2017 Oct;29(11):2183-2194. (IF 1.718)
32. Fu Q, Li C, Yu L
.
Gambogic acid inhibits spinal cord injury and inflammation through suppressing the p38 and Akt signaling pathways.
Mol Med Rep. 2018 Jan;17(1):2026-2032. (IF 2.1)
33. Dai J, Gu L, Su Y, Wang Q, Zhao Y, Chen X, Deng H, Li W, Wang G, Li K
.
Inhibition of curcumin on influenza A virus infection and influenzal pneumonia via oxidative stress, TLR2/4, p38/JNK MAPK and NF-κB pathways.
Int Immunopharmacol. 2018 Jan;54:177-187. (IF 3.943)
34. Qiao H, Ren H, Du H, Zhang M, Xiong X, Lv R
.
Liraglutide repairs the infarcted heart: The role of the SIRT1/Parkin/mitophagy pathway.
Mol Med Rep. 2018 Mar;17(3):3722-3734. (IF 2.1)
35. Zhao L, Qi L, Li C, Li L, Jin L, Yuan J.
.
SVCV impairs mitochondria complex Ⅲ resulting in accumulation of hydrogen peroxide.
FISH SHELLFISH IMMUN. 2018 Apr;75:58-65. (IF 3.298)
36. Zhang QL, Wang W, Jiang Y, A-Tuya, Dongmei, Li LL, Lu ZJ, Chang H, Zhang TZ
.
GRGM-13 comprising 13 plant and animal products, inhibited oxidative stress induced apoptosis in retinal ganglion cells by inhibiting P2RX7/p38 MAPK signaling pathway.
Biomed Pharmacother. 2018 May;101:494-500. (IF 4.545)
37. Xu E, Chen M, Zheng J, Maimaitiming Z, Zhong T, Chen H
.
Deletion of hephaestin and ceruloplasmin induces a serious systemic iron deficiency and disrupts iron homeostasis.
BIOCHEM BIOPH RES CO. 2018 Sep 10;503(3):1905-1910. (IF 2.985)
38. Zhang D, Li Y, Zhang T, Liu J, Jahejo AR, Yang L, Chen P, Ning G, Huo N, Ma H, Yan F, Tian W
.
Protective effects of zinc and N-acetyl-L-cysteine supplementation against cadmium induced erythrocyte cytotoxicity in Arbor Acres broiler chickens (Gallus gallus domesticus).
ECOTOX ENVIRON SAFE. 2018 Nov 15;163:331-339. (IF 4.872)
39. Ding X, Sun W, Chen J
.
IL-2 augments the sorafenib-induced apoptosis in liver cancer by promoting mitochondrial fission and activating the JNK/TAZ pathway.
Cancer Cell Int. 2018 Nov 9;18:176. (IF 4.175)
40. Zhang X, Högy P, Wu X, Schmid I, Wang X, Schulze WX, Jiang D, Fangmeier A
.
Physiological and Proteomic Evidence for the Interactive Effects of Post-Anthesis Heat Stress and Elevated CO2 on Wheat.
Proteomics. 2018 Dec;18(23):e1800262. (IF 3.254)
41. Xu S, Zhao X, Liu F, Cao Y, Wang B, Wang X, Yin M, Wang Q, Feng X
.
Crucial role of oxidative stress in bactericidal effect of parthenolide against Xanthomonas oryzae pv. oryzae.
Pest Manag Sci. 2018 Dec;74(12):2716-2723. (IF 3.75)
42. Wu Z, Wang Y, Meng X, Wang X, Li Z, Qian S, Wei Y, Shu L, Ding Y, Wang P, Peng Y
.
Total C-21 steroidal glycosides, isolated from the root tuber of Cynanchum auriculatum Royle ex Wight, attenuate hydrogen peroxide-induced oxidative injury and inflammation in L02 cells.
Int J Mol Med. 2018 Dec;42(6):3157-3170. (IF 3.098)
43. Zhang L, Li S, Wang R, Chen C, Ma W, Cai H
.
Cytokine augments the sorafenib-induced apoptosis in Huh7 liver cancer cell by inducing mitochondrial fragmentation and activating MAPK-JNK signalling pathway.
Biomed Pharmacother. 2019 Feb 110:213-223. (IF 4.545)
44. Alboghobeish S, Mahdavinia M, Zeidooni L, Samimi A, Oroojan AA, Alizadeh S, Dehghani MA, Ahangarpour A, Khorsandi L
.
Efficiency of naringin against reproductive toxicity and testicular damages induced by bisphenol A in rats.
Iran J Basic Med Sci. 2019 Mar 22(3):315-523. (IF 2.146)
45. Qin QJ, Cui LQ, Li P, Wang YB, Zhang XZ, Guo ML
.
Rhynchophylline ameliorates myocardial ischemia/reperfusion injury through the modulation of mitochondrial mechanisms to mediate myocardial apoptosis.
Mol Med Rep. 2019 Apr 19(4):2581-2590. (IF 2.1)
46. Sun X, Li X, Jia H, Loor JJ, Bucktrout R, Xu Q, Wang Y, Shu X, Dong J, Zuo R, Yang L, Liu G, Li X
.
Effect of heat-shock protein B7 on oxidative stress in adipocytes from preruminant calves.
J Dairy Sci. 2019 Jun 102(6):5673-5685. (IF 3.333)
47. Qiu WJ, Xu MZ, Zhu XD, Ji YH
.
MicroRNA-27a alleviates IL-1β-induced inflammatory response and articular cartilage degradation via TLR4/NF-κB signaling pathway in articular chondrocytes.
Int Immunopharmacol. 2019 Nov 76:105839. (IF 3.943)
48. Hang Yu, Zhidian Wu, Xiaozhi Wang, Chang Gao, Run Liu, Fuxin Kang, Mingming Dai
.
Protective effects of combined treatment with mild hypothermia and edaravone against cerebral ischemia/reperfusion injury via oxidative stress and Nrf2 pathway regulation
Int J Oncol. 2020 Aug;57(2):500-508. doi: 10.3892/ijo.2020.5077. (IF 3.899)
49. Yangyang Chen, Jichun Tang, Yinghong Zhang, Juan Du, Yuanli Wang, Hui Yu, Yanling He
.
Astaxanthin alleviates gestational diabetes mellitus in mice through suppression of oxidative stress
Naunyn Schmiedebergs Arch Pharmacol. 2020 Dec;393(12):2517-2527. doi: 10.1007/s00210-020-01861-x.
50. Yue Wu, Cunlin Gu, L U Huang, Yuanqing Zhao, Yanjun Tang, Hongqian Zhao, Qiong Wu
.
Hypoxia preconditioning improves structure and function of astrocytes mitochondria via PGC-1α/HIF signal
J Biosci. 2021;46:7.
51. Yike Yang, Ping Xu, Fangyu Zhu, Jiujiang Liao, Yue Wu, Mingyu Hu, Huijia Fu, Juan Qiao, Li Lin, Biao Huang, Huili Jin, Xiyao Liu, Yangxi Zheng, Li Wen, Richard Saffery, Mark D Kilby, Jianying Yan, Louise C Kenny, Hongbo Qi, Chao Tong, Philip N Baker
.
The Potent Antioxidant MitoQ Protects Against Preeclampsia During Late Gestation but Increases the Risk of Preeclampsia When Administered in Early Pregnancy
Antioxid Redox Signal. 2021 Jan 10;34(2):118-136. doi: 10.1089/ars.2019.7891.
52. Xiuzhen Hou, Junfeng Zhang, Hehong Ma, Ming Li, Pei Wang
.
Hypoxia-reoxygenation treatment attenuates gestational diabetes mellitus
Endocr Connect. 2021 Jan;10(1):84-91. doi: 10.1530/EC-20-0555. (IF 2.592)
53. Xiao-Huan Zhang, Chen-Cong Zhou, Chong-Yong Li, Yao Hua, Kang Li, Ping Wei, Ming-Fang He
.
Isoliquiritin exert protective effect on telencephalon infarction injury by regulating multi-pathways in zebrafish model of ischemic stroke
Phytomedicine. 2021 Mar;83:153469. doi: 10.1016/j.phymed.2021.153469. (IF 4.268)
54. Qiushi Xu, Yunhui Fan, Juan J Loor, Yusheng Liang, Xudong Sun, Hongdou Jia, Chenxu Zhao, Chuang Xu
.
Adenosine 5'-monophosphate-activated protein kinase ameliorates bovine adipocyte oxidative stress by inducing antioxidant responses and autophagy
J Dairy Sci. 2021 Apr;104(4):4516-4528. doi: 10.3168/jds.2020-18728. (IF 3.333)
55. Xiao Cui, Yongshi Ma, Hong Wang, Jianfang Huang, Linlin Li, Jianbing Tang, Biao Cheng
.
The Anti-photoaging Effects of Pre- and Post-treatment of Platelet-rich Plasma on UVB-damaged HaCaT Keratinocytes
Photochem Photobiol. 2021 May;97(3):589-599. doi: 10.1111/php.13354. (IF 2.721)
56. Yongshi Ma, Min Xuan, Yunqing Dong, Hong Wang, Jianfang Huang, Biao Cheng, Xiao Cui
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Platelet-rich plasma protects human melanocytes from oxidative stress and ameliorates melanogenesis induced by UVB irradiation
Biosci Biotechnol Biochem. 2021 Jun 24;85(7):1686-1696. doi: 10.1093/bbb/zbab085.
57. Runpu Li, Yingxin Qu, Xiaoqi Li, Ye Tao, Qinghua Yang, Junyi Wang, Yumei Diao, Qian Li, Yifan Fang, Yifei Huang, Liqiang Wang
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Molecular Hydrogen Attenuated N-methyl-N-Nitrosourea Induced Corneal Endothelial Injury by Upregulating Anti-Apoptotic Pathway
Invest Ophthalmol Vis Sci. 2021 Jul 1;62(9):2. doi: 10.1167/iovs.62.9.2.
58. Li Ma, Chengxu Li, Shuai Lian, Bin Xu, Hongming Lv, Yanzhi Liu, Jingjing Lu, Hong Ji, Shize Li, Jingru Guo, Huanmin Yang
.
Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy
J Cell Mol Med. 2021 Aug;25(16):8015-8027. doi: 10.1111/jcmm.16733. (IF 4.486)
59. Yan He, Yuanzhu Sun, Jun Peng
.
Circ_0114428 Regulates Sepsis-Induced Kidney Injury by Targeting the miR-495-3p/CRBN Axis
Inflammation. 2021 Aug;44(4):1464-1477. doi: 10.1007/s10753-021-01432-z. (IF 3.212)
60. Yuxia Feng, Yuxin Hu, Pengpeng Fang, Xiangjun Zuo, Jinxiong Wang, Jiana Li, Wei Qian, Jiaqin Mei
.
Silicon Alleviates the Disease Severity of Sclerotinia Stem Rot in Rapeseed
Front Plant Sci. 2021 Sep 13;12:721436. doi: 10.3389/fpls.2021.721436. (IF 4.402)
61. Yaping Zhan, Minxia Zhu, Shang Liu, Jiayue Lu, Zhaohui Ni, Hong Cai, Weiming Zhang
.
MicroRNA‑93 inhibits the apoptosis and inflammatory response of tubular epithelial cells via the PTEN/AKT/mTOR pathway in acute kidney injury
Mol Med Rep. 2021 Sep;24(3):666. doi: 10.3892/mmr.2021.12305. (IF 2.1)
62. Qiancheng Mu, Yuxuan Zhang, Long Gu, Stefan T Gerner, Xiancheng Qiu, Qianke Tao, Jinwei Pang, Ghosh Dipritu, Lifang Zhang, Shigang Yin, Yong Jiang, Jianhua Peng
.
Transcriptomic Profiling Reveals the Antiapoptosis and Antioxidant Stress Effects of Fos in Ischemic Stroke
Front Neurol. 2021 Oct 21;12:728984. doi: 10.3389/fneur.2021.728984. (IF 2.889)
63. QingJian Liang, WenNa Dong, FeiFei Wang, WeiNa Wang, Jian Zhang, Xing Liu
.
Ficus hirta Vahl. promotes antioxidant enzyme activity under ammonia stress by inhibiting miR-2765 expression in Penaeus vannamei
Ecotoxicol Environ Saf. 2021 Nov 15;228:112989. doi: 10.1016/j.ecoenv.2021.112989.
64. Jingtao Jiang, Chengji Dong, Liang Zhai, Junsheng Lou, Jie Jin, Sheng Cheng, Zhuliu Chen, Xiaoshan Guo, Damu Lin, Jian Ding, Weiyang Gao
.
Paeoniflorin Suppresses TBHP-Induced Oxidative Stress and Apoptosis in Human Umbilical Vein Endothelial Cells via the Nrf2/HO-1 Signaling Pathway and Improves Skin Flap Survival
Front Pharmacol. 2021 Nov 4;12:735530. doi: 10.3389/fphar.2021.735530. (IF 4.225)
66. Kun Ma, Hao-Yu Wu, Sheng-Yuan Wang, Bai-Xiang Li
.
The Keap1/Nrf2-ARE signaling pathway is involved in atrazine induced dopaminergic neurons degeneration via microglia activation
Ecotoxicol Environ Saf. 2021 Dec 15;226:112862. doi: 10.1016/j.ecoenv.2021.112862.
67. Juanping Yin, Xinke Chen
.
Edaravone prevents high glucose-induced injury in retinal Müller cells through thioredoxin1 and the PGC-1α/NRF1/TFAM pathway
Pharm Biol. 2021 Dec;59(1):1233-1244. doi: 10.1080/13880209.2021.1972123. (IF 2.971)
68. Guang-Hui Chen, Chang-Chun Song, Kostas Pantopoulos, Xiao-Lei Wei, Hua Zheng, Zhi Luo
.
Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway
Free Radic Biol Med. 2022 Feb 20:180:95-107. doi: 10.1016/j.freeradbiomed.2022.01.012.
69. Rui Wang, Jinjin Pan, Jinzhen Han, Miaomiao Gong, Liang Liu, Yunlong Zhang, Ying Liu, Dingyou Wang, Qing Tang, Na Wu, Lin Wang, Jinsong Yan, Hua Li, Yuhui Yuan
.
Melatonin Attenuates Dasatinib-Aggravated Hypoxic Pulmonary Hypertension via Inhibiting Pulmonary Vascular Remodeling
Front Cardiovasc Med. 2022 Mar 24:9:790921. doi: 10.3389/fcvm.2022.790921.
70. Bingxin Zheng, Yixin Zheng, Ningning Zhang, Yi Zhang, Baodong Zheng
.
Rhoifolin from Plumula Nelumbinis exhibits anti-cancer effects in pancreatic cancer via AKT/JNK signaling pathways
Sci Rep. 2022 Apr 5;12(1):5654. doi: 10.1038/s41598-022-09581-3.
71. Lili Song, Congjun Li, Fei Wu, Shicui Zhang
.
Dietary intake of diosgenin delays aging of male fish Nothobranchius guentheri through modulation of multiple pathways that play prominent roles in ROS production
Biogerontology. 2022 Apr;23(2):201-213. doi: 10.1007/s10522-022-09955-0. (IF 3.667)
72. Jie Song, Jinxiang Wang
.
SIRT3 regulates bronchial epithelium apoptosis and aggravates airway inflammation in asthma
Mol Med Rep. 2022 Apr;25(4):144. doi: 10.3892/mmr.2022.12660. (IF 2.1)
73. Xinghui Wang, Mengyao Zhu, Juan J Loor, Qianming Jiang, Yiwei Zhu, Wei Li, Xiliang Du, Yuxiang Song, Wenwen Gao, Lin Lei, Jianguo Wang, Guowen Liu, Xinwei Li
.
Propionate alleviates fatty acid-induced mitochondrial dysfunction, oxidative stress, and apoptosis by upregulating PPARG coactivator 1 alpha in hepatocytes
J Dairy Sci. 2022 May;105(5):4581-4592. doi: 10.3168/jds.2021-21198. (IF 3.333)
74. Zi-Run Jin, Ya-Lei Cao, Zhi-Chao Luo, Qian-Cheng Zhao, Yu Xi, Jia-Ming Weng, Zhe Zhang, Hui Jiang
.
Therapeutic Effects of Xianlu Oral Solution on Rats with Oligoasthenozoospermia through Alleviating Apoptosis and Oxidative Stress
Evid Based Complement Alternat Med. 2022 Jun 18:2022:1269530. doi: 10.1155/2022/1269530.
75. Cuicui Zhang, Hai Niu, Chengyu Wan, Xiuxian Yu, Guang Xin, Yuda Zhu, Zeliang Wei, Fan Li, Yilan Wang, Kun Zhang, Shiyi Li, Yuman Dong, Yangying Li, Wen Huang
.
Drug D, a Diosgenin Derive, Inhibits L-Arginine-Induced Acute Pancreatitis through Meditating GSDMD in the Endoplasmic Reticulum via the TXNIP/HIF-1α Pathway
Nutrients. 2022 Jun 22;14(13):2591. doi: 10.3390/nu14132591. (IF 4.546)
76. Disi Deng, Jin Yan, Wanjing Li, Yeke Wu, Keming Wu
.
Protective Effect of XinJiaCongRongTuSiZiWan on the Reproductive Toxicity of Female Rats Induced by Triptolide
Evid Based Complement Alternat Med. 2022 Jun 6:2022:3642349. doi: 10.1155/2022/3642349.
77. Lili Song, Fei Wu, Congjun Li, Shicui Zhang
.
Dietary intake of GDF11 delays the onset of several biomarkers of aging in male mice through anti-oxidant system via Smad2/3 pathway
Biogerontology. 2022 Jun;23(3):341-362. doi: 10.1007/s10522-022-09967-w. (IF 3.667)
78. Yinhong Niu, Jiale Liao, Haitao Zhou, Chih-Chen Wang, Lei Wang, Yanli Fan
.
Flavonoids from Lycium barbarum Leaves Exhibit Anti-Aging Effects through the Redox-Modulation
Molecules. 2022 Aug 3;27(15):4952. doi: 10.3390/molecules27154952. (IF 3.267)
79. Bingru Nan, Xia Sun, Jie Zhang, Qingyu Huang, Xi Zhang, Yanbo Li, Junchao Duan, Rui Chen, Zhiwei Sun, Heqing Shen
.
Accumulated oxidative stress risk in HUVECs by chronic exposure to non-observable acute effect levels of PM2.5
Toxicol In Vitro. 2022 Aug:82:105376. doi: 10.1016/j.tiv.2022.105376. (IF 2.959)
80. Lili Song, Kailiang Leng, Kun Xiao, Shicui Zhang
.
Administration of krill oil extends lifespan of fish Nothobranchius guentheri via enhancement of antioxidant system and suppression of NF-κB pathway
Fish Physiol Biochem. 2022 Aug;48(4):1057-1073. doi: 10.1007/s10695-022-01102-3. (IF 2.242)
81. Guang-Hui Liu, Dian-Guang Zhang, Xi-Jun Lei, Xiao-Ying Tan, Chang-Chun Song, Hua Zheng, Zhi Luo
.
Effects of Dietary Selenium and Oxidized Fish Oils on Intestinal Lipid Metabolism and Antioxidant Responses of Yellow Catfish Pelteobagrus fulvidraco
Antioxidants (Basel). 2022 Sep 26;11(10):1904. doi: 10.3390/antiox11101904.
82. Yangying Li, Yuda Zhu, Shiyi Li, Yuman Dong, Chengyu Wan, Xiuxian Yu, Guang Xin, Zeliang Wei, Fan Li, Yilan Wang, Kun Zhang, Qingqiu Chen, Cuicui Zhang, E Wen, Hai Niu, Wen Huang
.
Deoxyarbutin attenuates severe acute pancreatitis via the HtrA2/PGC-1α pathway
Free Radic Res. 2022 Sep-Oct;56(9-10):651-665. doi: 10.1080/10715762.2022.2163244.
83. Shuqin Du, Hanqiang Shi, Lie Xiong, Ping Wang, Yanbo Shi
.
Canagliflozin mitigates ferroptosis and improves myocardial oxidative stress in mice with diabetic cardiomyopathy
Front Endocrinol (Lausanne). 2022 Oct 14:13:1011669. doi: 10.3389/fendo.2022.1011669.
84. Tianyi Wang, Tingting Zhou, Mingming Xu, Shuo Wang, Anqi Wu, Mingyang Zhang, You Lang Zhou, Jiahai Shi
.
Platelet membrane-camouflaged nanoparticles carry microRNA inhibitor against myocardial ischaemia‒reperfusion injury
J Nanobiotechnology. 2022 Oct 4;20(1):434. doi: 10.1186/s12951-022-01639-8.
85. Dongyu Lei, Biao Li, Zuribia Isa, Xiaoqiang Ma, Baojian Zhang
.
Hypoxia-elicited cardiac microvascular endothelial cell-derived exosomal miR-210-3p alleviate hypoxia/reoxygenation-induced myocardial cell injury through inhibiting transferrin receptor 1-mediated fe
Tissue Cell. 2022 Dec:79:101956. doi: 10.1016/j.tice.2022.101956. (IF 1.837)
86. Yuqiong Li, Huiyu Wen, Yuwei Yang, Zhengwei Zhao, Haihui Gao, Hongbing Li, Meizhou Huang
.
Potential prognostic markers of retained placenta in dairy cows identified by plasma metabolomics coupled with clinical laboratory indicators
Vet Q. 2022 Dec;42(1):199-212. doi: 10.1080/01652176.2022.2145619.
87. Ruilin Hao, Shuhua Shan, Dandan Yang, Huimin Zhang, Yi Sun, Zhuoyu Li
.
Peonidin-3-O-Glucoside from Purple Corncob Ameliorates Nonalcoholic Fatty Liver Disease by Regulating Mitochondrial and Lysosome Functions to Reduce Oxidative Stress and Inflammation
Nutrients. 2023 Jan 11;15(2):372. doi: 10.3390/nu15020372.
88. Zhengkang Su, Kaiyu Guan, Yunbin Liu, Hai Zhang, Zhengwei Huang, Miaomiao Zheng, Ya Zhu, He Zhang, Weihong Song, Xi Li
.
Developmental and behavioral toxicity assessment of opicapone in zebrafish embryos
Ecotoxicol Environ Saf. 2023 Jan 1:249:114340. doi: 10.1016/j.ecoenv.2022.114340.
89. Quan Zhou, Weikai Chen, Chao Gu, Hao Liu, Xiayu Hu, Lei Deng, Wei He, Yong Xu, Xuesong Zhu, Huilin Yang, Xi Chen, Fan He, Tao Liu
.
Selenium-modified bone cement promotes osteoporotic bone defect repair in ovariectomized rats by restoring GPx1-mediated mitochondrial antioxidant functions
Regen Biomater. 2023 Feb 14:10:rbad011. doi: 10.1093/rb/rbad011.
90. Hanfang Zeng, Shujie Li, Yunfei Zhai, Haomiao Chang, Zhaoyu Han
.
Preliminary Transcriptome Analysis of Long Noncoding RNA in Hypothalamic-Pituitary-Mammary Gland Axis of Dairy Cows under Heat Stress
Biomolecules. 2023 Feb 18;13(2):390. doi: 10.3390/biom13020390.
91. Zitong Meng, Yuxiao Liao, Zhao Peng, Xiaolei Zhou, Huanhuan Zhou, Andreas K Nüssler, Liegang Liu, Wei Yang
.
Bone Marrow Mesenchymal Stem-Cell-Derived Exosomes Ameliorate Deoxynivalenol-Induced Mice Liver Damage
Antioxidants (Basel). 2023 Feb 27;12(3):588. doi: 10.3390/antiox12030588.
92. Patrick Maduabuchi Aja, Hilary Akobi Ogwoni, Peter Chinedu Agu, Ejike Ugbala Ekpono, Joshua Nonso Awoke, Oliver Ugochukwu Ukachi, Obasi Uche Orji, Boniface Anthony Ale, Chinonso Peter Nweke, Ikechukwu Okorie Igwenyi, Esther Ugo Alum, Darlington C Chukwu, Christian E Offor, Atamgba Agbor Asuk, Ejike Daniel Eze, Ojochenemi E Yakubu, J B Akobi, Onyedika Gabriel Ani, Chinaza Godswill Awuchi
.
Cucumeropsis mannii seed oil protects against Bisphenol A-induced testicular mitochondrial damages
Food Sci Nutr. 2023 Feb 7;11(6):2631-2641. doi: 10.1002/fsn3.3260.
93. Rongjin Yang, Xiaomeng Zhang, Yunyun Zhang, Yingfan Wang, Man Li, Yuancui Meng, Jianbang Wang, Xue Wen, Jun Yu, Pan Chang
.
Grpel2 maintains cardiomyocyte survival in diabetic cardiomyopathy through DLST-mediated mitochondrial dysfunction: a proof-of-concept study
J Transl Med. 2023 Mar 16;21(1):200. doi: 10.1186/s12967-023-04049-y.
94. Bozhu Lin, Xiaorong Zhang
.
Vitamin E Supplement Protects Against Gestational Diabetes Mellitus in Mice Through nuclear factor-erythroid factor 2-related factor 2/heme oxygenase-1 Signaling Pathway
Diabetes Metab Syndr Obes. 2023 Mar 1:16:565-574. doi: 10.2147/DMSO.S397255.
95. Sajin Zhou, Hongyan Zhu, Piaopiao Xiong, Lei Shi, Weibin Bai, Xiaoling Li
.
Spore Oil-Functionalized Selenium Nanoparticles Protect Pancreatic Beta Cells from Palmitic Acid-Induced Apoptosis via Inhibition of Oxidative Stress-Mediated Apoptotic Pathways
Antioxidants (Basel). 2023 Mar 30;12(4):840. doi: 10.3390/antiox12040840.
96. Xian Zhang, Keni Cui, Xiaolu Wang, Yuanyuan Tong, Chihong Liu, Yuechao Zhu, Qidong You, Zhengyu Jiang, Xiaoke Guo
.
Novel Hydrogen Sulfide Hybrid Derivatives of Keap1-Nrf2 Protein-Protein Interaction Inhibitor Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis
Antioxidants (Basel). 2023 May 8;12(5):1062. doi: 10.3390/antiox12051062.
97. Jie Xu, Xin-Ling Wang, Han-Fang Zeng, Zhao-Yu Han
.
Methionine alleviates heat stress-induced ferroptosis in bovine mammary epithelial cells through the Nrf2 pathway
Ecotoxicol Environ Saf. 2023 May:256:114889. doi: 10.1016/j.ecoenv.2023.114889.
98. Libangxi Liu, Yuyao Zhang, Jiawei Fu, Xuezheng Ai, Dan Long, Xue Leng, Yang Zhang, Bo Huang, Changqing Li, Yue Zhou, Chencheng Feng
.
Gli1 depletion induces oxidative stress and apoptosis of nucleus pulposus cells via Fos in intervertebral disc degeneration
J Orthop Translat. 2023 Jun 13:40:116-131. doi: 10.1016/j.jot.2023.05.008.
99. Zi-Xian Zhou, Qi Cui, Ying-Mei Zhang, Jia-Xin Yang, Wen-Jing Xiang, Ning Tian, Yan-Lin Jiang, Mei-Ling Chen, Bin Yang, Qing-Hua Li, Ru-Jia Liao
.
Withaferin A inhibits ferroptosis and protects against intracerebral hemorrhage
Neural Regen Res. 2023 Jun;18(6):1308-1315. doi: 10.4103/1673-5374.355822.
100. Cui Ma, Xiaoying Wang, Lixin Zhang, Xiangrui Zhu, June Bai, Siyu He, Jian Mei, Jiaqi Jiang, Xiaoyu Guan, Xiaodong Zheng, Lihui Qu, Daling Zhu
.
Super Enhancer-Associated Circular RNA-CircKrt4 Regulates Hypoxic Pulmonary Artery Endothelial Cell Dysfunction in Mice
Arterioscler Thromb Vasc Biol. 2023 Jul;43(7):1179-1198. doi: 10.1161/ATVBAHA.122.318842.
101. Meiran Chu, Xinglan An, Cong Fu, Hao Yu, Daoyu Zhang, Qi Li, Xiaxia Man, Xiangpeng Dai, Ziyi Li
.
Disulfiram/Copper Induce Ferroptosis in Triple-Negative Breast Cancer Cell Line MDA-MB-231
Front Biosci (Landmark Ed). 2023 Aug 28;28(8):186. doi: 10.31083/j.fbl2808186.
102. Xuan Wang, Yuting Ji, Jingyi Qi, Shuaishuai Zhou, Sitong Wan, Chang Fan, Zhenglong Gu, Peng An, Yongting Luo, Junjie Luo
.
Mitochondrial carrier 1 (MTCH1) governs ferroptosis by triggering the FoxO1-GPX4 axis-mediated retrograde signaling in cervical cancer cells
Cell Death Dis. 2023 Aug 8;14(8):508. doi: 10.1038/s41419-023-06033-2.
103. Yuanshui Liu, Hang Yang, Fei Zhu, Yanhong Ouyang, Pinhua Pan
.
Inhibition of STAT3 phosphorylation by colchicine regulates NLRP3 activation to alleviate sepsis-induced acute lung injury
Inflammopharmacology. 2023 Aug;31(4):2007-2021. doi: 10.1007/s10787-023-01199-9.
104. Yizhao Zhou, Zhen Jia, Jing Wang, Shu Huang, Shu Yang, Sheng Xiao, Duo Xia, Yi Zhou
.
Curcumin reverses erastin-induced chondrocyte ferroptosis by upregulating Nrf2
Heliyon. 2023 Sep 20;9(10):e20163. doi: 10.1016/j.heliyon.2023.e20163.
106. Yanwei Wang, Jiahui Zhao, Yipeng Xu, Cimin Tao, Jie Tong, Yingjie Luo, Yong Chen, Xuesong Liu, Tengfei Xu
.
Uncovering SOD3 and GPX4 as new targets of Benzo[α]pyrene-induced hepatotoxicity through Metabolomics and Chemical Proteomics
Redox Biol. 2023 Nov:67:102930. doi: 10.1016/j.redox.2023.102930.
107. Pei Lin, Hong-Yu Shi, Yin-Ying Lu, Jun Lin
.
Centella asiatica alleviates psoriasis through JAK/STAT3-mediated inflammation: An in vitro and in vivo study
J Ethnopharmacol. 2023 Dec 5:317:116746. doi: 10.1016/j.jep.2023.116746.
108. Chenchen Zhao, Jinxia Li, Menglin Liu, Linfang Chen, Yiwei Zhu, Wenwen Gao, Xiliang Du, Yuxiang Song, Guowen Liu, Lin Lei, Xinwei Li
.
Inhibition of cluster antigen 36 protects against fatty acid-induced lipid accumulation, oxidative stress, and inflammation in bovine hepatocytes
J Dairy Sci. 2023 Dec;106(12):9186-9199. doi: 10.3168/jds.2023-23282.
109. Dingxin Liu, Fei Cao, Zhifeng Xu, Chunhua Zhao, Zekun Liu, Jiadong Pang, Ze-Xian Liu, Mahdieh Moghiseh, Anthony Butler, Shaoxia Liang, Weijun Fan, Jiang Yang
.
Selective Organ-Targeting Hafnium Oxide Nanoparticles with Multienzyme-Mimetic Activities Attenuate Radiation-Induced Tissue Damage
Adv Mater. 2024 May;36(19):e2308098. doi: 10.1002/adma.202308098.
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