- 询价
- DIMA
- 武汉
- DME900237
- 2025年07月15日
- Mouse
- Human, Dog, Rat, Monkey, Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
IgG2b
- 形态：
请咨询
- 保存条件：
Store at -20°C
- 克隆性：
单克隆
- 标记物：
Unconjugated
- 适应物种：
Human, Dog, Rat, Monkey, Mouse
- 保质期：
请咨询
- 级别：
仅用于科研
- 库存：
1 week
- 供应商：
缔码生物（武汉）科技有限公司
- 宿主：
Mouse
- 浓度：
请咨询
- 靶点：
Chk2
- 抗体英文名：
Biotinylated Anti-B7-H2 antibody(DM98); Rabbit mAb
- 抗体名：
Biotinylated Anti-B7-H2 antibody(DM98); Rabbit mAb
- 规格：
100ul
| 背景 | In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition,this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Three transcript variants encoding different isoforms have been found for this gene. |
|---|---|
| 别名 | CDS1; CHK2; hCds1; HuCds1; LFS2; PP1425; RAD53 |
| 推荐稀释比 | WB 1:500~1000, IF 1:50~100, FLOW 1:100 |
| 组分&重悬 | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| 纯化 | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Uniprot ID | O96017 |
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文献和实验T-Cell Activation Using mAb to CD3
splenic T-cells and human peripheral T cells stimulated via CD3. Critical parameters include cell density, antibody titer and activation kinetics. Materials 1X sterile PBS Anti-mouse CD3e, Clone 145-2C11 (Functional Grade, Cat. No. 16
Purification of mAb (IgG) by Chang-Duk Jun, 03/14/2000 Purpose Materials Antibody 7E3 , 2L sup grown in flasks, frozen and thawed overnight. BioRad Affi-Gel Protein A MAPS II Buffers
Immunohistochemistry using Anti-Ganglioside Antibodies
supernatant containing antiganglioside mAb overnight at 4°C. The time of incubation may range from 30 min. to overnight as determined by experience. 5. Wash with 1% BSA in PBS 4 times. 6. Incubate in FITC-conjugated goat anti-mouse IgM F(ab
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