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- PME48646
- 2025年07月11日
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- 保存条件：
-80°C
- 保质期：
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- 英文名：
Human RAG2 (NM_000536) Protein
- 库存：
1 week
- 供应商：
缔码生物（武汉）科技有限公司
- 规格：
50 ug
| 产品类别 | ECD Proteins |
|---|---|
| 靶点 | RAG2 |
| Uniprot ID | P55895 |
| 背景 | This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq, Jul 2008] |
| 描述 | Purified recombinant protein of Human recombination activating gene 2 (RAG2), transcript variant 1, full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug |
| 分子量 | 87.1 kDa |
| 纯度 | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| 别名 | RAG-2 |
| 标签 | N-GST and C-His |
| 表达宿主 | E. coli |
| 组分与重悬 | 50mM Tris, pH8.0,8M Urea. |
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Characterization of HIV-1 Infection in the Humanized Rag2/c/ Mouse Model
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