ACETAMIDE,2-CYANO-N-[1-(4-ETHY

Synthesis of Triazole‐Nucleoside Phosphoramidites and Their Use in Solid‐Phase Oligonucleotide Synthesis

N ‐(2‐(tert ‐Butyldimethylsilyloxy)ethyl)‐uracil‐1‐yl‐N ‐(prop‐2‐ynyl)acetamide (15 ; protocol 3 ) Ethyl 2‐(N ‐(2‐azidoethyl)‐uracil‐1‐yl‐acetamido)acetate (16

Synthesis and Properties of 7‐Substituted 7‐Deazapurine (Pyrrolo[2,3‐d]pyrimidine) 2′‐Deoxyribonucleosides

of 7‐bromo‐7‐deaza‐2′‐deoxyisoguanosine (S.4c ) is carried out by glycosylation of a brominated nucleobase followed by amination at C4 and selective deamination at C2′. NBS, N ‐bromosuccinimide; Piv, pivaloyl; TDA‐1, tris[2‐(2‐methoxyethoxy)ethyl]amine

Time‐Dependent Thermocontrol of the Hydrophilic and Lipophilic Properties of DNA Oligonucleotide Prodrugs

of the hydroxyalkylated phosphoramidate (S.19 ) and phosphoramidothioate derivatives (S.20 ‐S.25 ). Abbreviations: DMTr, 4,4′‐dimethoxytrityl; Et, ethyl; i ‐Pr, isopropyl; N(CH2 CH2 )2 O, morpholinyl. Adapted from Grajkowski et al. (). Reproduced by permission