Rabbit Polyclonal Anti-PJA1 An

gene_symbol：CADM3
predicted_size：Predicted: 71 kDa; Observed: 71 kDa
Uniprot ID：Q8NG27
description：Rabbit Polyclonal Anti-PJA1 Antibody
clonality：Polyclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：Ubiquitinization is an important cellular degradation process requiring sequential reactions that are mediated by three enzymes: E1, E2 and E3. PJA1, also known as Praja1 and RING finger protein 70, is a 643 amino acid E2-dependent E3-ubiquitin ligase that is abundantly expressed in the brain (1,2). Through interaction and activation with the E2-ubiquitin ligase UBC4, PJA1 mediates substrate-specific ubiquitination via its RING finger domain and facilitates ubiquitination (3). Overexpression of PJA1 in gastrointestinal cancers suggests that it may be responsible for the degradation of some anti-oncogenic proteins (4,5).
immunogen：PJA1 antibody was raised against a 19 amino acid peptide near the amino terminus of human PJA1.
recommended_dilution：WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
predicted_size：Predicted: 71 kDa; Observed: 71 kDa
buffer：PBS containing 0.02% sodium azide.
host_species：Rabbit
applications：IF, IHC, WB
reactivities：Human, Mouse, Rat