Claudin 9 (CLDN9) rat monoclon

gene_symbol：CLDN9
predicted_size：null
Uniprot ID：O95484
description：Claudin 9 (CLDN9) rat monoclonal antibody, clone YD-4E9, Purified
clonality：Monoclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：Claudin 9 belongs to the claudin family which constitutes a large group of four - transmembrane domain proteins (1). Claudins are integral tight junction proteins that are responsible for maintaining the integrity of epithelial cell architecture, the control of paracellular transport and c ell polarity. The expression pattern of claudins is tissue specific, most tissues express multiple claudins, which can interact in both homotypic and heterotypic fashion to form the tight junction strands (2). Several claudin proteins have been shown to be abnormally expressed in cancers. The differential expression of these proteins between tumour and normal cells, in addition to their membrane localisation, makes them prime candidates for cancer therapy (2). Members of the claudin family, including Claudi n 6 and 9 are expressed in the liver and play a critical role in Hepatitis C Infection. They function as coreceptors in HCV entry and assume a role in HCV dissemination, replication and pathogenesis (3,4) .
immunogen：cDNA encoding Human Claudin 9.  Selection: based on recognition of the complete native protein expressed on transfected mammalian cells.
recommended_dilution：Flow Cytometry: 1.2 µg / 10⁶ cells. ELISA: 1/200-1/400. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400. CELISA: 1/200-1/400.
predicted_size：null
buffer：PBS, pH 7.2; State: Purified; State: Liquid purified Ig fraction; Preservative: None
host_species：Rat
applications：ELISA, FC
reactivities：Human