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Description:Recombinant TGF beta 2 (Transforming growth factor beta 2),Human
Accn
Unipro ID:P61812
Synonyms:G-TSF, LDS4, TGFB2
Species:Human
Amount:20 ug
Delivery time:2周
Expression sequence:MALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS with polyhistidine tag at the C-terminus.
Tags:His Tag (C-term)
PredictedMW:The protein has a calculated MW of 13.66 kDa. The protein migrates as 15 kDa under reducing condition (SDS-PAGE analysis).
Buffer:The protein was lyophilized from a 0.2 µm filtered solution containing 20 mM sodium citrate, 0.2 M NaCl, pH 3.5.
Stability
Bioactivity:Measure by its ability to inhibit IL-4-induce proliferation in HT-2 cells. The ED₅₀ for this effect is 5 x 10⁶ IU/mg.
Purity:>98% as determined by SDS-PAGE.
Concentration
Preparation
Endotoxin:<0.01 EU per 1 μg of the protein by the LAL method.
Shipping
Background:Transforming Growth Factors beta 2 (TGFβ-2) is a 12.85 kDa member of the epidermal Growth Factors with 113 amino acid residues. TGFβ-2 is expressed from throughout the body. TGFβ-2 is a regulator of cell proliferation, differentiation, apoptosis, cell plasticity and migration, etc. TGF-β-2 also associates with various kinds of diseases, such as cancer and tissue fibrosis.
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文献和实验Transforming Growth Factor Beta: A Plasma Tumor Marker
are prostate-specific antigen (PSA), carcinoembryonic antigen (CEA), β-human chorionic gonadotropin (β-HCG), and CA-125. Tumor markers may be specific for certain tumors, such as PSA for prostate cancer, or more generally expressed, such as CEA.
Transforming Growth Factor-Beta: Recent Advances on Its Role in Immune Tolerance
Transforming growth factor (TGF- β1) is a pleiotropic cytokine, secreted by immune and nonhematopoietic cells. TGF-β is involved in many different critical processes, such as embryonal development, cellular maturation and differentiation
Excessive scarring (fibrosis) is a major cause of pathologies in multiple tissues, including lung, liver, kidney, heart, cornea, and skin. The transforming growth factor-β (TGF-β) system has been shown to play a key role in regulating
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