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Description:Recombinant Neurturin,Human
Accn
Unipro ID:Q99748
Synonyms:NTN, NRTN
Species:Human
Amount:20 ug
Delivery time:2周
Expression sequence:MARLGARPCGLRELEVRVSELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYEDEVSFLDAHSRYHTVHELSARECACV with polyhistidine tag at the C-terminus.
Tags:His Tag (C-term)
PredictedMW:The protein has a calculated MW of 12.62 kDa. The protein migrates as 13 kDa under reducing condition (SDS-PAGE analysis).
Buffer:The protein was lyophilized from a 0.2 µm filtered solution containing 1X PBS, pH 7.4.
Stability
Bioactivity:Measure by its ability to induce proliferation in SH-SY5Y cells. The ED₅₀ for this effect is <50 ng/mL.
Purity:>98% as determined by SDS-PAGE.
Concentration
Preparation
Endotoxin:<0.1 EU per 1 μg of the protein by the LAL method.
Shipping
Background:Human Neurturin is a 22 kDa cytokine with 197 amino acid residues. Neurturin belongs to the same TGF-beta (transforming Growth Factors β) family. When Neurturin binds to GFRα-2 (GPI-linked receptor termed GDNF family receptor α-2), this complex activates Ret receptor tyrosine kinase and its downstream signaling pathway.
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