Purified recombinant protein o

gene_symbol：Complement C4A
Description：Purified recombinant protein of Human complement component 4A (Rodgers blood group) (C4A), Lys20-End, with C-terminal His tag, secretory expressed in HEK293 cells, 50ug
Accn：NM_007293
Unipro ID：P0C0L4
Synonyms：C4; C4A2; C4A3; C4A4; C4A6; C4AD; C4S; CO4; CPAMD2; RG
Species：Human
Amount：50 ug
Delivery time：4周
Expression sequence：A DNA sequence from TrueORF clone, [RC215339], encoding the region(Lys20-End) of C4A
Tags：C-HIS
PredictedMW：191.8 kDa
Buffer：PBS, pH 7.4, 10% glycerol
Stability：Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Bioactivity
Purity：> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration：>0.05 µg/µL as determined by microplate BCA method
Preparation
Endotoxin
Shipping
Background：This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]