VEGF-A mouse recombinant prote

gene_symbol：Vegfa
Description：VEGF-A mouse recombinant protein, 20 µg
Accn：NM_001025250
Unipro ID：Q00731
Synonyms：VEGFA, VEGF, VPF, Vascular endothelial growth factor A, Vascular permeability factor
Species：Mouse
Amount：20 ug
Delivery time：7周
Expression sequence：APTTEGEQKS HEVIKFMDVY QRSYCRPIET LVDIFQEYPD EIEYIFKPSC VPLMRCAGCC NDEALECVPT SESNITMQIM RIKPHQSQHI GEMSFLQHSR CECRPKKDRT KPEKKSVRGK GKGQKRKKKS RFKSWSVHCE PCSERRKHLF VQDPQTCKCS CKNTDSRCKA RQLELNERTC RCDKPRR
Tags
PredictedMW：44.2 kDa
Buffer：Presentation State: PurifiedState: Lyophilized proteinBuffer System: 50 mM Acetic AcidStabilizer: None
Stability：Shelf life: one year from despatch.
Bioactivity：Biological: Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 2-20 ng/ml.
Purity：>95% by SDS-PAGE and silver stain
Concentration
Preparation：Lyophilized protein
Endotoxin：< 0.1 ng/µg of VEGF188
Shipping
Background：This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.[provided by RefSeq, Nov 2015]