Recombinant protein of human B

gene_symbol：BMI1
Description：Recombinant protein of human BMI1 polycomb ring finger oncogene (BMI1), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Accn：NM_005180
Unipro ID：P35226
Synonyms：flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51
Species：Human
Amount：50 ug
Delivery time：现货
Expression sequence：A DNA sequence encoding human full-length BMI1
Tags：N-His
PredictedMW：36.9 kDa
Buffer：25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 100 mM arginine, 10% glycerol
Stability：Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Bioactivity：In vitro kinase assay substrate (PMID: 28270146)Binding assay (competitor) (PMID: 29402932)
Purity：> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration：>0.05 µg/µL as determined by microplate BCA method
Preparation
Endotoxin
Shipping
Background：This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]