Recombinant protein of human B

gene_symbol：BMP2
Description：Recombinant protein of human Bone Morphogenetic Protein-2 (BMP2) produced in E. coli.
Accn：NM_001200
Unipro ID：P12643
Synonyms：BDA2; BMP2A; SSFSC; SSFSC1
Species：Human
Amount：20 ug
Delivery time：3周
Expression sequence：A DNA sequence encoding the region (Gln283-Arg396) of human BMP2
Tags：Tag Free
PredictedMW：13 kDa
Buffer：Lyophilized from a sterile solution containing 10 mM sodium citrate, pH 3.5
Stability：Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Bioactivity：Measured?by?its?ability?to?induce?alkaline?phosphatase?production in?ATDC5?cells. ED50 for this effect is typically 36 - 55 ng/ml.Co-immunoprecipitation (PMID: 28009989)
Purity：>95% as determined by SDS-PAGE and Coomassie blue staining
Concentration：Resuspend the protein to the desired concentration in proper buffer.
Preparation
Endotoxin：< 0.1 EU per 1 µg of the protein by the LAL
Shipping
Background：This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]