Purified recombinant protein o

gene_symbol：ATF1
Description：Purified recombinant protein of Human activating transcription factor 1 (ATF1)
Accn：NM_005171
Unipro ID：P18846
Synonyms：EWS-ATF1; FUS/ATF-1; TREB36
Species：Human
Amount：10 ug
Delivery time：2周
Expression sequence：Met1-Val271
Tags：C-His
PredictedMW：30.3 kDa
Buffer：Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Stability：Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Bioactivity
Purity：>95% as determined by SDS-PAGE and Coomassie blue staining
Concentration：lot specific
Preparation
Endotoxin：Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
Shipping
Background：This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]