Rabbit Polyclonal anti-TLR4 An

gene_symbol：TLR4
predicted_size：null
Uniprot ID：O26
description：Rabbit Polyclonal anti-TLR4 Antibody
clonality：Polyclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain. [provided by RefSeq]
immunogen：Developed against a synthetic peptide corresponding to amino acids 420-435 of human TLR4.
recommended_dilution：FC, IHC, ICC, WB
predicted_size：null
buffer：PBS pH7.4, 50% glycerol
host_species：Rabbit
applications：IHC, WB
reactivities：Human, Mouse