HSD17B1 Rabbit Monoclonal Anti

ProductName：HSD17B1 Rabbit Monoclonal Antibody [Clone ID: OTIR1E5]
description：HSD17B1 Rabbit monoclonal antibody,clone OTIR1E5
symbol：HSD17B1
synonyms：null
locusid：3292
Concentration：1 mg/ml
sub_category：Primary Antibodies
uniprot_id：P14061
Applications：WB
CNdelivery：现货
RecommendDilution：WB1:2000
Reactivity：Human
Immunogen：Human recombinant protein fragment of Human HSD17B1 (NP_000404) produced in E. coli.
Purification：Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation：Unconjugated
ProteinFamilies：null
ProteinPathways：null
GeneName：hydroxysteroid 17-beta dehydrogenase 1
Background：This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Buffer：PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
isotypes_filter：IgG
predicted_size：35KD