Exportin 4 (XPO4) Rabbit Monoc

ProductName：Exportin 4 (XPO4) Rabbit Monoclonal Antibody [Clone ID: R09-1A2]
description：XPO4 Rabbit monoclonal Antibody
symbol：XPO4
synonyms：Exp4; FLJ13046; KIAA1721
locusid：64328
Concentration：lot specific
sub_category：Primary Antibodies
uniprot_id：Q9C0E2
Applications：IP, WB
CNdelivery：2周
RecommendDilution：WB: 1/1000-1/5000
IP: 1/20-1/50
Reactivity：Human, Rat
Immunogen：A synthetic peptide of human Exportin 4
Purification：Affinity Purified
Conjugation：Unconjugated
ProteinFamilies：null
ProteinPathways：null
GeneName：exportin 4
Background：Swiss-Prot Acc.Q9C0E2.Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Buffer：50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
isotypes_filter：IgG
predicted_size：Calculated MW: 130 kDa; Observed MW: 130 kDa