SP1 Rabbit Monoclonal Antibody

ProductName：SP1 Rabbit Monoclonal Antibody [Clone ID: R06-9I9]
description：SP1 Rabbit monoclonal Antibody
symbol：SP1
synonyms：TSFP1
locusid：6667
Concentration：lot specific
sub_category：Primary Antibodies
uniprot_id：P08047
Applications：IF, IHC, IP, WB
CNdelivery：2周
RecommendDilution：WB: 1/1000
IHC: 1/100
ICC/IF: 1/20
IP: 1/20
Reactivity：Human
Immunogen：Recombinant protein of human SP1
Purification：Affinity Purified
Conjugation：Unconjugated
ProteinFamilies：null
ProteinPathways：null
GeneName：Sp1 transcription factor
Background：Swiss-Prot Acc.P08047.Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1.
Buffer：50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
isotypes_filter：IgG
predicted_size：Calculated MW: 81 kDa; Observed MW: 90 kDa