PERK (EIF2AK3) Rabbit Monoclon

ProductName：PERK (EIF2AK3) Rabbit Monoclonal Antibody [Clone ID: R09-1F9]
description：PERK Rabbit monoclonal Antibody
symbol：EIF2AK3
synonyms：DKFZp781H1925; HRI; HsPEK; PEK; PERK; WRS
locusid：9451
Concentration：lot specific
sub_category：Primary Antibodies
uniprot_id：Q9NZJ5
Applications：WB
CNdelivery：2周
RecommendDilution：WB: 1/1000
Reactivity：Human, Mouse, Rat
Immunogen：Recombinant protein of human PERK
Purification：Affinity Purified
Conjugation：Unconjugated
ProteinFamilies：null
ProteinPathways：null
GeneName：eukaryotic translation initiation factor 2 alpha kinase 3
Background：Swiss-Prot Acc.Q9NZJ5.Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.
Buffer：50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
isotypes_filter：IgG
predicted_size：Calculated MW: 125 kDa; Observed MW: 140 kDa